Biol Reprod Keystone Symposia Conference on Frontiers in Reproductive Biology & Regulation of Fertility.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Meredith, S.
Right arrow Articles by Butcher, R. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Meredith, S.
Right arrow Articles by Butcher, R. L.
Agricola
Right arrow Articles by Meredith, S.
Right arrow Articles by Butcher, R. L.

Biology of Reproduction, Vol 32, 788-794, Copyright © 1985 by Society for the Study of Reproduction

ARTICLES

Role of decreased numbers of follicles on reproductive performance in young and aged rats

S Meredith and RL Butcher

The primary objectives of this study were to: 1) determine if removal of 1.5 ovaries from young rats would mimic reproductive characteristics that normally occur with advancing age and 2) determine if removal of 1.5 ovaries from aged rats would further advance the process of reproductive aging. Removal of 1.5 ovaries increased the number of young (P less than 0.05) and old (P less than 0.01) rats that exhibited abnormal estrous cycles. In addition, concentrations of follicle- stimulating hormone (FSH) were higher at both ages in the groups with half an ovary. The increased concentrations of FSH are consistent with a decrease in the number of growing follicles after removal of 1.5 ovaries. All groups had lower concentrations of estradiol (E2) than young controls. There was a significant increase in the number of abnormal embryos with age and removal of 1.5 ovaries when rats were mated during a 5-day estrous cycle, but there was no effect if they were mated during a 4-day estrous cycle. From the results of this study, we conclude that the reduction in ovarian tissue in young and aged rats mimicked several reproductive characteristics of advancing age. Also, an effect of aging on the hypothalamus was evident in this study.


This article has been cited by other articles:


Home page
 Reproductive SciencesHome page
J. Yeh and B. Kim
Increasing Blunting of Inhibin Responses to Dynamic Ovarian Challenge Is Associated With Reproductive Aging in the Rat
Reproductive Sciences, January 1, 2007; 14(1): 10 - 19.
[Abstract] [PDF]

Home page
 Hum ReprodHome page
V.A. Akande, C.F. Fleming, L.P. Hunt, S.D. Keay, and J.M. Jenkins
Biological versus chronological ageing of oocytes, distinguishable by raised FSH levels in relation to the success of IVF treatment
Hum. Reprod., August 1, 2002; 17(8): 2003 - 2008.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
C. R. Anzalone, L.-S. Hong, J. K.H. Lu, and P. S. LaPolt
Influences of Age and Ovarian Follicular Reserve on Estrous Cycle Patterns, Ovulation, and Hormone Secretion in the Long-Evans Rat
Biol Reprod, April 1, 2001; 64(4): 1056 - 1062.
[Abstract] [Full Text]

Home page
 Biol. Reprod.Home page
P. S. LaPolt, D. W. Matt, and J. K.H. Lu
Progesterone Implants Delay Age-Related Declines in Regular Estrous Cyclicity and the Ovarian Follicular Reserve in Long-Evans Rats
Biol Reprod, July 1, 1998; 59(1): 197 - 201.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1985 by the Society for the Study of Reproduction.