| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Biology of Reproduction, Vol 33, 423-431, Copyright © 1985 by Society for the Study of Reproduction
ARTICLES |
AK Dubey and TM Plant
Four orchidectomized rhesus monkeys (3-3.5 yr of age) were treated for 62 days with daily i.m. injections of hydrocortisone acetate (HCA) at a dose of 10-20 mg/(kg BW X day), and blood samples were obtained daily or every other day before, during, and after treatment. Hydrocortisone acetate injections resulted in a progressive rise in mean plasma cortisol from basal concentrations of 17-35 micrograms/100 ml prior to initiation of steroid treatment to approximately 150 micrograms/100 ml 5 wk later. When serum cortisol concentrations reached 100 micrograms/100 ml, 3-4 wk after the initiation of HCA treatment, circulating luteinizing hormone (LH) and follicle-stimulating hormone (FSH) began to decline, reaching nondetectable concentrations 35 days later. Withdrawal of HCA resulted in a return in plasma cortisol concentrations to pretreatment control levels, which was associated with a complete restoration of gonadotropin secretion. In 2 animals, administration of an intermittent i.v. infusion of gonadotropin- releasing hormone (GnRH) (0.1 micrograms/min for 3 min once every hour), which appears to stimulate the gonadotropes in a physiologic manner, reversed the cortisol-induced inhibition of gonadotropin secretion, restoring circulating LH and FSH concentrations to within 80- 100% of control. These results suggest that, in the rhesus monkey, the major site of the inhibitory action of cortisol on gonadotropin release resides at a suprapituitary level and is mediated by interruption of hypothalamic GnRH release.
This article has been cited by other articles:
|
|
 |
|
  A. E. Oakley, K. M. Breen, I. J. Clarke, F. J. Karsch, E. R. Wagenmaker, and A. J. Tilbrook Cortisol Reduces Gonadotropin-Releasing Hormone Pulse Frequency in Follicular Phase Ewes: Influence of Ovarian Steroids Endocrinology, January 1, 2009; 150(1): 341 - 349. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Breen, A. E. Oakley, A. V. Pytiak, A. J. Tilbrook, E. R. Wagenmaker, and F. J. Karsch Does Cortisol Acting Via the Type II Glucocorticoid Receptor Mediate Suppression of Pulsatile Luteinizing Hormone Secretion in Response to Psychosocial Stress? Endocrinology, April 1, 2007; 148(4): 1882 - 1890. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Stackpole, I. J. Clarke, K. M. Breen, A. I. Turner, F. J. Karsch, and A. J. Tilbrook Sex Difference in the Suppressive Effect of Cortisol on Pulsatile Secretion of Luteinizing Hormone in Sheep Endocrinology, December 1, 2006; 147(12): 5921 - 5931. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. G. Thackray, S. M. McGillivray, and P. L. Mellon Androgens, Progestins, and Glucocorticoids Induce Follicle-Stimulating Hormone {beta}-Subunit Gene Expression at the Level of the Gonadotrope Mol. Endocrinol., September 1, 2006; 20(9): 2062 - 2079. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Breen, C. A. Stackpole, I. J. Clarke, A. V. Pytiak, A. J. Tilbrook, E. R. Wagenmaker, E. A. Young, and F. J. Karsch Does the Type II Glucocorticoid Receptor Mediate Cortisol-Induced Suppression in Pituitary Responsiveness to Gonadotropin-Releasing Hormone? Endocrinology, June 1, 2004; 145(6): 2739 - 2746. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Breen and F. J. Karsch Does Cortisol Inhibit Pulsatile Luteinizing Hormone Secretion at the Hypothalamic or Pituitary Level? Endocrinology, February 1, 2004; 145(2): 692 - 698. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Levine Editorial: Stressing the Importance of Sex Endocrinology, December 1, 2002; 143(12): 4502 - 4504. [Full Text] [PDF]
|
|
|
|
|
|
N. Debus, K. M. Breen, G. K. Barrell, H. J. Billings, M. Brown, E. A. Young, and F. J. Karsch Does Cortisol Mediate Endotoxin-Induced Inhibition of Pulsatile Luteinizing Hormone and Gonadotropin-Releasing Hormone Secretion? Endocrinology, October 1, 2002; 143(10): 3748 - 3758. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Lado-Abeal, J. D. Veldhuis, and R. L. Norman Glucose Relays Information Regarding Nutritional Status to the Neural Circuits That Control the Somatotropic, Corticotropic, and Gonadotropic Axes in Adult Male Rhesus Macaques Endocrinology, February 1, 2002; 143(2): 403 - 410. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. M. Oltmanns, B. Fruehwald-Schultes, W. Kern, J. Born, H. L. Fehm, and A. Peters Hypoglycemia, But Not Insulin, Acutely Decreases LH and T Secretion in Men J. Clin. Endocrinol. Metab., October 1, 2001; 86(10): 4913 - 4919. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. J. Hayes, S. DeCruz, S. B. Seminara, P. A. Boepple, and W. F. Crowley Jr. Differential Regulation of Gonadotropin Secretion by Testosterone in the Human Male: Absence of a Negative Feedback Effect of Testosterone on Follicle-Stimulating Hormone Secretion J. Clin. Endocrinol. Metab., January 1, 2001; 86(1): 53 - 58. [Abstract] [Full Text]
|
|
|
|
 |
|
 T.-J. Huang and P. Shirley Li Dexamethasone Inhibits Luteinizing Hormone-Induced Synthesis of Steroidogenic Acute Regulatory Protein in Cultured Rat Preovulatory Follicles Biol Reprod, January 1, 2001; 64(1): 163 - 170. [Abstract] [Full Text]
|
|
|
|
 |
|
 R. M. Sapolsky, L. M. Romero, and A. U. Munck How Do Glucocorticoids Influence Stress Responses? Integrating Permissive, Suppressive, Stimulatory, and Preparative Actions Endocr. Rev., February 1, 2000; 21(1): 55 - 89. [Abstract] [Full Text]
|
|
|
|
|
|
B. N. Roy, R. L. Reid, and D. A. Van Vugt The Effects of Estrogen and Progesterone on Corticotropin-Releasing Hormone and Arginine Vasopressin Messenger Ribonucleic Acid Levels in the Paraventricular Nucleus and Supraoptic Nucleus of the Rhesus Monkey Endocrinology, May 1, 1999; 140(5): 2191 - 2198. [Abstract] [Full Text]
|
|
|
|
|
|
J.-G. Yang, W.-Y. Chen, and P. S. Li Effects of Glucocorticoids on Maturation of Pig Oocytes and Their Subsequent Fertilizing Capacity In Vitro Biol Reprod, April 1, 1999; 60(4): 929 - 936. [Abstract] [Full Text]
|
|
|
|
 |
|
 U. R. Chandran, B. S. Warren, C. T. Baumann, G. L. Hager, and D. B. DeFranco The Glucocorticoid Receptor Is Tethered to DNA-bound Oct-1 at the Mouse Gonadotropin-releasing Hormone Distal Negative Glucocorticoid Response Element J. Biol. Chem., January 22, 1999; 274(4): 2372 - 2378. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.A. Daley, H. Sakurai, B.M. Adams, and T.E. Adams Effect of Stress-Like Concentrations of Cortisol on Gonadotroph Function in Orchidectomized Sheep Biol Reprod, January 1, 1999; 60(1): 158 - 163. [Abstract] [Full Text]
|
|
|
|
|
|
T.E. Adams, H. Sakurai, and B.M. Adams Effect of Stress-Like Concentrations of Cortisol on Estradiol-Dependent Expression of Gonadotropin-Releasing Hormone Receptor in Orchidectomized Sheep Biol Reprod, January 1, 1999; 60(1): 164 - 168. [Abstract] [Full Text]
|
|
|
|
|
|
J. Lado-Abeal, J. Rodriguez-Arnao, J. D. C. Newell-Price, L. A. Perry, A. B. Grossman, G. M. Besser, and P. J. Trainer Menstrual Abnormalities in Women with Cushing's Disease Are Correlated with Hypercortisolemia Rather Than Raised Circulating Androgen Levels J. Clin. Endocrinol. Metab., September 1, 1998; 83(9): 3083 - 3088. [Abstract] [Full Text]
|
|
|
|
|
|
J. Hangaard, M. Andersen, E. Grodum, O. Koldkjær, and C. Hagen Pulsatile Luteinizing Hormone Secretion in Patients with Addison's Disease. Impact of Glucocorticoid Substitution J. Clin. Endocrinol. Metab., March 1, 1998; 83(3): 736 - 743. [Abstract] [Full Text]
|
|
|
|
|
|
D. F. Battaglia, J. M. Bowen, H. B. Krasa, L. A. Thrun, C. Viguie, and F. J. Karsch Endotoxin Inhibits the Reproductive Neuroendocrine Axis While Stimulating Adrenal Steroids: A Simultaneous View from Hypophyseal Portal and Peripheral Blood Endocrinology, October 1, 1997; 138(10): 4273 - 4281. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Van Vugt, J. Piercy, A. E. Farley, R. L. Reid, and S. Rivest Luteinizing Hormone Secretion and Corticotropin-Releasing Factor Gene Expression in the Paraventricular Nucleus of Rhesus Monkeys Following Cortisol Synthesis Inhibition Endocrinology, June 1, 1997; 138(6): 2249 - 2258. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. R. Chandran, B. Attardi, R. Friedman, Z.-w. Zheng, J. L. Roberts, and D. B. DeFranco Glucocorticoid Repression of the Mouse Gonadotropin-releasing Hormone Gene Is Mediated by Promoter Elements That Are Recognized by Heteromeric Complexes Containing Glucocorticoid Receptor J. Biol. Chem., August 23, 1996; 271(34): 20412 - 20420. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
