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Biology of Reproduction, Vol 33, 899-901, Copyright © 1985 by Society for the Study of Reproduction

ARTICLES

Estrogen-induced increase in eosinophil number and peroxidase activity in uterus of genetically mast cell-deficient W/Wv mice

N Terada, T Yamane, K Matsumoto, H Asai and Y Kitamura

The role of mast cells in induction of uterine eosinophilia was investigated by using genetically mast cell-deficient (WB X C57BL/6)F1- W/Wv (hereafter called WBB6F1-W/Wv) mice. The injection of estradiol-17 beta (0.16 micrograms/g body weight) increased the peroxidase activity and eosinophil number in the uteri of castrated WBB6F1-W/Wv and WBB6F1- +/+ mice. Since no significant differences were detectable between these two type of mice, mast cells did not seem to be essential for the estrogen-induced uterine eosinophilia, at least in mice.




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Copyright © 1985 by the Society for the Study of Reproduction.