Biol Reprod Keystone Symposia Conference on Frontiers in Reproductive Biology & Regulation of Fertility.
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Biology of Reproduction, Vol 33, 1105-1112, Copyright © 1985 by Society for the Study of Reproduction

ARTICLES

Binding of the calcium antagonist [3H] nitrendipine to human myometrial plasmalemma

AM Golichowski and DY Tzeng

Membrane fragments were prepared from nonpregnant human myometrium and fractionated by differential and sucrose gradient centrifugation. Reversible high-affinity binding sites of the dihydropyridine calcium antagonist nitrendipine were identified in highest density in that membrane fraction most enriched in markers for plasmalemma. In determinations done on several preparations, the equilibrium dissociation constant for nitrendipine at 37 degrees C was found to be 0.3 to 0.8 nM and was the same for each fraction. The maximum binding capacity was found to be 400-500 fmol/mg protein in the plasmalemma fraction.




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Copyright © 1985 by the Society for the Study of Reproduction.