Biol Reprod Keystone Symposia Conference on Frontiers in Reproductive Biology & Regulation of Fertility.
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Biology of Reproduction, Vol 36, 557-561, Copyright © 1987 by Society for the Study of Reproduction

ARTICLES

Impotence induced by a single gene mutation

C Chubb and L Henry

Inbred male mice homozygous for the stubby gene mutation were reported to be sterile nineteen years ago. However, the basis of the sterility has not been identified since testicular steroidogenesis and spermatogenesis are normal. In the present studies, the sexual behavior of stubby mice and their coisogenic, normal siblings was compared quantitatively. The experimental observations provided unequivocal evidence that the phenotypic basis of the sterility of stubby mice is impotency. Stubby mice represent the first animal model for the study of impotence and provide the first evidence of an autosomal gene mutation that has a primary effect on male sexual behavior.


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J.-Y. Jiang, M. Umezu, and E. Sato
Characteristics of Infertility and the Improvement of Fertility by Thyroxine Treatment in Adult Male Hypothyroid rdw Rats
Biol Reprod, December 1, 2000; 63(6): 1637 - 1641.
[Abstract] [Full Text]


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Copyright © 1987 by the Society for the Study of Reproduction.