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Biology of Reproduction, Vol 36, 606-610, Copyright © 1987 by Society for the Study of Reproduction

ARTICLES

Linkage of the preimplantation-embryo-development (Ped) gene to the mouse major histocompatibility complex (MHC)

CM Warner, SO Gollnick and SB Goldbard

The preimplantation-embryo-development (Ped) gene influences the rate of cleavage division of preimplantation mouse embryos. The location of the Ped gene in the mouse major histocompatibility complex (MHC), the H- 2 complex, has been inferred from the analysis of cleavage rates of embryos from mouse strains congenic at the H-2 complex. In this paper, formal genetic linkage studies were undertaken to evaluate linkage of the Ped gene to the H-2 complex. Co-segregation of Ped gene phenotype and H-2 haplotype was found in back-cross embryos. These data support the hypothesis that the Ped gene is linked to the H-2 complex.


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