Biol Reprod Keystone Symposia Conference on Frontiers in Reproductive Biology & Regulation of Fertility.
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Biology of Reproduction, Vol 36, 611-616, Copyright © 1987 by Society for the Study of Reproduction

ARTICLES

Analysis of Qa-2 antigen expression by preimplantation mouse embryos: possible relationship to the preimplantation-embryo-development (Ped) gene product

CM Warner, SO Gollnick, L Flaherty and SB Goldbard

The preimplantation-embryo-development (Ped) gene, a gene that controls the cleavage rate of preimplantation mouse embryos, maps to the Qa-2 subregion of the mouse major histocompatibility complex (MHC). A highly sensitive enzyme-linked immunosorbent assay (ELISA) procedure was used to detect Qa-2 antigens on mouse embryos. The use of a monoclonal antibody specific for Qa-2 antigens showed that Qa-2 antigens were present on oocytes, 2-cell, 8-cell, and blastocyst-stage embryos, with the greatest expression found on blastocysts. Expression of Qa-2 antigens by the embryos correlated completely with Ped gene phenotype. Those embryos expressing the fast Ped allele showed the presence of Qa- 2 antigens (Qa-2a mice), whereas those embryos expressing the slow Ped allele showed the absence of Qa-2 antigens (Qa-2b mice). It is hypothesized that the Qa-2 antigen may be the Ped gene product.


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A. Watkins, A. Wilkins, C. Osmond, C. M. Warner, M. Comiskey, M. Hanson, and T. P. Fleming
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Cross-linking of Qa-2 protein, the Ped gene product, increases the cleavage rate of C57BL/6 preimplantation mouse embryos
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W. Cao, C. A. Brenner, M. Alikani, J. Cohen, and C. M. Warner
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L. Wu, H. Feng, and C. M. Warner
Identification of Two Major Histocompatibility Complex Class Ib Genes, Q7 and Q9, as the Ped Gene in the Mouse
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L. Wu, G. E. Exley, and C. M. Warner
Differential Expression of Ped Gene Candidates in Preimplantation Mouse Embryos
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B. Koller, P Marrack, J. Kappler, and O Smithies
Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells
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Copyright © 1987 by the Society for the Study of Reproduction.