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Biology of Reproduction, Vol 38, 1077-1083, Copyright © 1988 by Society for the Study of Reproduction

ARTICLES

Full term development of mouse eggs fertilized by a spermatozoon microinjected under the zona pellucida

JR Mann
Centre for Early Human Development, Monash University, Clayton, Victoria, Australia.

A mature motile mouse spermatozoon was microinjected under the zona pellucida of mouse eggs. Twenty-five percent of eggs were fertilized, and 54% of these developed to normal fetuses or to term after transfer to pseudopregnant recipients. These results provide a quantitative estimate of the minimum proportion of spermatozoa in a population that are able to contribute to normal development--at least 54% of mature individuals that were able to fertilize the egg after microinjection, or at least 13 1/2% (25% of 54%) of the total population of mature sperm. The production of normal young shows that sperm microinjection is a feasible means for the treatment of severe male infertility in the human and in other species.


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