Biology of Reproduction, Vol 40, 972-980, Copyright © 1989 by Society for the Study of Reproduction

ARTICLES

The hypogonadotropic state of the prepubertal male rhesus monkey (Macaca mulatta) is not associated with a decrease in hypothalamic gonadotropin-releasing hormone content [published erratum appears in Biol Reprod 1989 Sep;41(3):following 558]

MO Fraser, CR Pohl and TM Plant
Department of Physiology, University of Pittsburgh School of Medicine, Pennsylvania 15261.

Hypothalamic contents of gonadotropin-releasing hormone (GnRH) in neonatally orchidectomized infant, juvenile, and adult monkeys were measured by a radioimmunoassay (RIA) and by an in vivo bioassay that utilized luteinizing hormone (LH) secretion in estrogen- and progesterone-treated ovariectomized rats. The results of the bioassay provided no evidence to suggest that hypothalamic GnRH content in juvenile monkeys (mean = 83 ng/hypothalamus; n = 3) was less than that in infants (mean = 54 ng/hypothalamus; n = 4) and adults (mean = 36 ng/hypothalamus; n = 3). A similar developmental pattern in hypothalamic GnRH content was also observed when the decapeptide was measured by RIA. In striking contrast to the maintenance of hypothalamic GnRH content throughout postnatal development, pituitary gonadotropin contents and serum gonadotropin concentrations were markedly reduced in juvenile monkeys.

This article has been cited by other articles:

				S. B. Seminara Converging at Puberty's Hub Endocrinology, November 1, 2007; 148(11): 5145 - 5146. [Full Text] [PDF]

				T. M Plant The role of KiSS-1 in the regulation of puberty in higher primates Eur. J. Endocrinol., November 1, 2006; 155(suppl_1): S11 - S16. [Abstract] [Full Text] [PDF]

				T. M. Plant, S. Ramaswamy, and M. J. DiPietro Repetitive Activation of Hypothalamic G Protein-Coupled Receptor 54 with Intravenous Pulses of Kisspeptin in the Juvenile Monkey (Macaca mulatta) Elicits a Sustained Train of Gonadotropin-Releasing Hormone Discharges Endocrinology, February 1, 2006; 147(2): 1007 - 1013. [Abstract] [Full Text] [PDF]

				F. J P Ebling The neuroendocrine timing of puberty Reproduction, June 1, 2005; 129(6): 675 - 683. [Abstract] [Full Text] [PDF]

				M. Shahab, C. Mastronardi, S. B. Seminara, W. F. Crowley, S. R. Ojeda, and T. M. Plant Increased hypothalamic GPR54 signaling: A potential mechanism for initiation of puberty in primates PNAS, February 8, 2005; 102(6): 2129 - 2134. [Abstract] [Full Text] [PDF]

				T. M. Plant and M. L. Barker-Gibb Neurobiological mechanisms of puberty in higher primates Hum. Reprod. Update, January 1, 2004; 10(1): 67 - 77. [Abstract] [Full Text] [PDF]

				V. S. Latimer, S. G. Kohama, V. T. Garyfallou, and H. F. Urbanski A Developmental Increase in the Expression of Messenger Ribonucleic Acid Encoding a Second Form of Gonadotropin-Releasing Hormone in the Rhesus Macaque Hypothalamus J. Clin. Endocrinol. Metab., January 1, 2001; 86(1): 324 - 329. [Abstract] [Full Text]

				M. E. Majdoubi, A. Sahu, and T. M. Plant Changes in Hypothalamic Gene Expression Associated with the Arrest of Pulsatile Gonadotropin-Releasing Hormone Release during Infancy in the Agonadal Male Rhesus Monkey (Macaca mulatta) Endocrinology, September 1, 2000; 141(9): 3273 - 3277. [Abstract] [Full Text] [PDF]

				M. E. Majdoubi, A. Sahu, S. Ramaswamy, and T. M. Plant Neuropeptide Y: A hypothalamic brake restraining the onset of puberty in primates PNAS, May 23, 2000; 97(11): 6179 - 6184. [Abstract] [Full Text] [PDF]