| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Biology of Reproduction, Vol 42, 239-245, Copyright © 1990 by Society for the Study of Reproduction
ARTICLES |
MC Wiltbank, MG Diskin, JA Flores and GD Niswender
Department of Physiology, Colorado State University, Fort Collins 80523.
This study was designed to examine the antisteroidogenic action of prostaglandin (PG) F2 alpha on ovine luteal cells in vitro. Purified populations of large and small steroidogenic luteal cells were treated with lipoproteins, luteinizing hormone (LH), and/or PGF2 alpha. To investigate the involvement of the protein kinase C (PKC) pathway in hormone action, luteal cells were made PKC-deficient by treatment for 12 h with 1 microM phorbol-12-myristate-13-acetate. Progesterone production by nonstimulated large and LH-stimulated small luteal cells was significantly increased by treatment with high- and low-density lipoprotein (HDL, 5-fold increase; LDL, 2-fold increase). PGF2 alpha inhibited (p less than 0.0001) progesterone production by HDL- stimulated large luteal cells in a dose-dependent manner, with 60 nM causing maximal inhibition. No effect of PGF2 alpha (20nM-20 microM) was found on production of progesterone by HDL-stimulated, PKC- deficient large cells or by LH- and HDL-stimulated small luteal cells. These results suggest that PGF2 alpha has a direct antisteroidogenic effect on the large luteal cell that is mediated through the PKC second messenger pathway.
This article has been cited by other articles:
|
|
 |
|
  R. L. Bogan and G. D. Niswender Constitutive Steroidogenesis in Ovine Large Luteal Cells May Be Mediated by Tonically Active Protein Kinase A Biol Reprod, August 1, 2007; 77(2): 209 - 216. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Sen, E. Choudhary, E. K. Inskeep, and J. A. Flores Effects of Selective Protein Kinase C Isozymes in Prostaglandin2{alpha}-Induced Ca2+ Signaling and Luteinizing Hormone-Induced Progesterone Accumulation in the Mid-Phase Bovine Corpus Luteum Biol Reprod, April 1, 2005; 72(4): 976 - 984. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. K. Yadav, G. Lakshmi, and R. Medhamurthy Prostaglandin F2{alpha}-mediated Activation of Apoptotic Signaling Cascades in the Corpus Luteum during Apoptosis: INVOLVEMENT OF CASPASE-ACTIVATED DNase J. Biol. Chem., March 18, 2005; 280(11): 10357 - 10367. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. J. Diaz and M. C. Wiltbank Acquisition of Luteolytic Capacity: Changes in Prostaglandin F2{alpha} Regulation of Steroid Hormone Receptors and Estradiol Biosynthesis in Pig Corpora Lutea Biol Reprod, May 1, 2004; 70(5): 1333 - 1339. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M Ohtani, S Takase, M P B Wijayagunawardane, M Tetsuka, and A Miyamoto Local interaction of prostaglandin F2{alpha} with endothelin-1 and tumor necrosis factor-{alpha} on the release of progesterone and oxytocin in ovine corpora lutea in vivo: a possible implication for a luteolytic cascade Reproduction, January 1, 2004; 127(1): 117 - 124. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. K. Yadav, R. R. Sudhagar, and R. Medhamurthy Apoptosis During Spontaneous and Prostaglandin F2{alpha}-Induced Luteal Regression in the Buffalo Cow (Bubalus bubalis): Involvementof Mitogen-Activated Protein Kinases Biol Reprod, September 1, 2002; 67(3): 752 - 759. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. T. Grazul-Bilska, L. P. Reynolds, J. J. Bilski, and D. A. Redmer Effects of Second Messengers on Gap Junctional Intercellular Communication of Ovine Luteal Cells Throughout the Estrous Cycle Biol Reprod, September 1, 2001; 65(3): 777 - 783. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.M. Burke, D.E. Spiers, F.N. Kojima, G.A. Perry, B.E. Salfen, S.L. Wood, D.J. Patterson, M.F. Smith, M.C. Lucy, W.G. Jackson, et al. Interaction of Endophyte-Infected Fescue and Heat Stress on Ovarian Function in the Beef Heifer Biol Reprod, July 1, 2001; 65(1): 260 - 268. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F.J. Diaz, T.D. Crenshaw, and M.C. Wiltbank Prostaglandin F2{alpha} Induces Distinct Physiological Responses in Porcine Corpora Lutea after Acquisition of Luteolytic Capacity Biol Reprod, November 1, 2000; 63(5): 1504 - 1512. [Abstract] [Full Text]
|
|
|
|
|
|
J.L. Juengel, J.D. Haworth, M.K. Rollyson, P.J. Silva, H.R. Sawyer, and G.D. Niswender Effect of Dose of Prostaglandin F2{alpha} on Steroidogenic Components and Oligonucleosomes in Ovine Luteal Tissue Biol Reprod, April 1, 2000; 62(4): 1047 - 1051. [Abstract] [Full Text]
|
|
|
|
 |
|
 G. D. Niswender, J. L. Juengel, P. J. Silva, M. K. Rollyson, and E. W. McIntush Mechanisms Controlling the Function and Life Span of the Corpus Luteum Physiol Rev, January 1, 2000; 80(1): 1 - 29. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. P. Fiedler, L. Jr. Plouffe, D. B. Hales, K. H. Hales, and I. Khan Prostaglandin F2{alpha} Induces a Rapid Decline in Progesterone Production and Steroidogenic Acute Regulatory Protein Expression in Isolated Rat Corpus Luteum Without Altering Messenger Ribonucleic Acid Expression Biol Reprod, September 1, 1999; 61(3): 643 - 650. [Abstract] [Full Text]
|
|
|
|
|
|
M.M. Ford, G.D. Thorburn, D.J. Caddy, and I.R. Young Pulsatile Output of Prostaglandin F2{alpha} Does Not Increase Around the Time of Luteolysis in the Pregnant Goat Biol Reprod, August 1, 1999; 61(2): 411 - 415. [Abstract] [Full Text]
|
|
|
|
|
|
J. A. McCracken, E. E. Custer, and J. C. Lamsa Luteolysis: A Neuroendocrine-Mediated Event Physiol Rev, April 1, 1999; 79(2): 263 - 323. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
