Biol Reprod Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gougeon, A.
Right arrow Articles by Thalabard, J. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gougeon, A.
Right arrow Articles by Thalabard, J. C.
Agricola
Right arrow Articles by Gougeon, A.
Right arrow Articles by Thalabard, J. C.

Biology of Reproduction, Vol 50, 653-663, Copyright © 1994 by Society for the Study of Reproduction

ARTICLES

Age-related changes of the population of human ovarian follicles: increase in the disappearance rate of non-growing and early-growing follicles in aging women

A Gougeon, R Echochard and JC Thalabard
INSERM U-355, Clamart, France.

The effect of aging on the number of non-growing follicles (NGF) and early-growing follicles (EGF) was studied in humans through use of a database obtained by pooling two subsets of ovarian pairs (2 x 43 pairs) collected in two distinct populations. A previously suggested model of exponential regression of NGF counts in relation to the subject's age was tested but did not adequately fit the observed data points. This lack of fit is attributable mainly to the existence of a significant relation between a woman's age and the corresponding NGF count decay rate. Consequently, various regression models were tested. Two different periods of decay rate were observed for each population of small follicles. The first corresponds to younger ages with a decay rate that is slow for both types of follicles, although faster for NGF than for EGF. The second period corresponds to older ages with an accelerated decay rate that appears similar for NGF and EGF. The changing points were found at 38.0 +/- 2.4 and 39.0 +/- 1.9 yr (mean +/- SD) for NGF and EGF, respectively. Extrapolation of the fitted model suggested the presence of approximately 402,000 healthy NGF per ovary at birth and a total exhaustion of the follicular stock at around 74 yr of age. These results support the view that depletion of the NGF pool is caused mainly by atresia in younger women but mainly by entrance of NGF into the growing pool in older women. The mechanisms triggering accelerated entrance into the growth phase of NGF are discussed in relation to the previously reported increase in FSH plasma levels that starts in the late thirties, approximately, and precedes the menopausal period by several years.


This article has been cited by other articles:


Home page
 Biol. Reprod.Home page
J.L.H. Ireland, D. Scheetz, F. Jimenez-Krassel, A.P.N. Themmen, F. Ward, P. Lonergan, G.W. Smith, G.I. Perez, A.C.O. Evans, and J.J. Ireland
Antral Follicle Count Reliably Predicts Number of Morphologically Healthy Oocytes and Follicles in Ovaries of Young Adult Cattle
Biol Reprod, December 1, 2008; 79(6): 1219 - 1225.
[Abstract] [Full Text] [PDF]

Home page
 Obstet GynecolHome page
T. Tulandi, J. Y. J. Huang, and S. L. Tan
Preservation of Female Fertility: An Essential Progress
Obstet. Gynecol., November 1, 2008; 112(5): 1160 - 1172.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
C. Gnoth, A.N. Schuring, K. Friol, J. Tigges, P. Mallmann, and E. Godehardt
Relevance of anti-Mullerian hormone measurement in a routine IVF program
Hum. Reprod., June 1, 2008; 23(6): 1359 - 1365.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. A. Cant and R. A. Johnstone
Reproductive conflict and the separation of reproductive generations in humans
PNAS, April 8, 2008; 105(14): 5332 - 5336.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
S. Rice, K. Ojha, and H. Mason
Human ovarian biopsies as a viable source of pre-antral follicles
Hum. Reprod., March 1, 2008; 23(3): 600 - 605.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
K. R. Hansen, N. S. Knowlton, A. C. Thyer, J. S. Charleston, M. R. Soules, and N. A. Klein
A new model of reproductive aging: the decline in ovarian non-growing follicle number from birth to menopause
Hum. Reprod., March 1, 2008; 23(3): 699 - 708.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
R. Soleimani, J. Van der Elst, E. Heytens, R. Van den Broecke, J. Gerris, M. Dhont, C. Cuvelier, and P. De Sutter
Back muscle as a promising site for ovarian tissue transplantation, an animal model
Hum. Reprod., March 1, 2008; 23(3): 619 - 626.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
D. A. Gook, D.H. Edgar, J. Borg, and M. Martic
Detection of zona pellucida proteins during human folliculogenesis
Hum. Reprod., February 1, 2008; 23(2): 394 - 402.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
J. S. Charleston, K. R. Hansen, A. C. Thyer, L. B. Charleston, A. Gougeon, J. R. Siebert, M. R. Soules, and N. A. Klein
Estimating human ovarian non-growing follicle number: the application of modern stereology techniques to an old problem
Hum. Reprod., August 1, 2007; 22(8): 2103 - 2110.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
K.P. Jones, L.C. Walker, D. Anderson, A. Lacreuse, S.L. Robson, and K. Hawkes
Depletion of Ovarian Follicles with Age in Chimpanzees: Similarities to Humans
Biol Reprod, August 1, 2007; 77(2): 247 - 251.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
M.L. Haadsma, A. Bukman, H. Groen, E.M.A. Roeloffzen, E.R. Groenewoud, M.J. Heineman, and A. Hoek
The number of small antral follicles (2-6 mm) determines the outcome of endocrine ovarian reserve tests in a subfertile population
Hum. Reprod., July 1, 2007; 22(7): 1925 - 1931.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
JJ. Ireland, F. Ward, F. Jimenez-Krassel, J.L.H. Ireland, G.W. Smith, P. Lonergan, and A.C.O. Evans
Follicle numbers are highly repeatable within individual animals but are inversely correlated with FSH concentrations and the proportion of good-quality embryos after ovarian stimulation in cattle
Hum. Reprod., June 1, 2007; 22(6): 1687 - 1695.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
M. K. Murphy, J. E. Hall, J. M. Adams, H. Lee, and C. K. Welt
Polycystic Ovarian Morphology in Normal Women Does Not Predict the Development of Polycystic Ovary Syndrome
J. Clin. Endocrinol. Metab., October 1, 2006; 91(10): 3878 - 3884.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
R.A. Anderson, A.P.N. Themmen, A.A. -Qahtani, N.P. Groome, and D.A. Cameron
The effects of chemotherapy and long-term gonadotrophin suppression on the ovarian reserve in premenopausal women with breast cancer
Hum. Reprod., October 1, 2006; 21(10): 2583 - 2592.
[Abstract] [Full Text] [PDF]

Home page
 Reproductive SciencesHome page
X. Zhang, X.-H. Li, X. Ma, Z.-H. Wang, S. Lu, and Y.-L. Guo
Redox-Induced Apoptosis of Human Oocytes in Resting Follicles In Vitro
Reproductive Sciences, September 1, 2006; 13(6): 451 - 458.
[Abstract] [PDF]

Home page
 Hum ReprodHome page
C.K. Welt, Y. Jimenez, P.M. Sluss, P.C. Smith, and J.E. Hall
Control of estradiol secretion in reproductive ageing
Hum. Reprod., August 1, 2006; 21(8): 2189 - 2193.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
N. S. Macklon, R. L. Stouffer, L. C. Giudice, and B. C. J. M. Fauser
The Science behind 25 Years of Ovarian Stimulation for in Vitro Fertilization
Endocr. Rev., April 1, 2006; 27(2): 170 - 207.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
Y. Wang, H. Newton, J. A. Spaliviero, C. M. Allan, B. Marshan, D. J. Handelsman, and P. J. Illingworth
Gonadotropin Control of Inhibin Secretion and the Relationship to Follicle Type and Number in the hpg Mouse
Biol Reprod, October 1, 2005; 73(4): 610 - 618.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
N. Fulton, S. J. Martins da Silva, R. A. L. Bayne, and R. A. Anderson
Germ Cell Proliferation and Apoptosis in the Developing Human Ovary
J. Clin. Endocrinol. Metab., August 1, 2005; 90(8): 4664 - 4670.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
R. A. Lobo
Potential Options for Preservation of Fertility in Women
N. Engl. J. Med., July 7, 2005; 353(1): 64 - 73.
[Full Text] [PDF]

Home page
 EndocrinologyHome page
T. Steckler, J. Wang, F. F. Bartol, S. K. Roy, and V. Padmanabhan
Fetal Programming: Prenatal Testosterone Treatment Causes Intrauterine Growth Retardation, Reduces Ovarian Reserve and Increases Ovarian Follicular Recruitment
Endocrinology, July 1, 2005; 146(7): 3185 - 3193.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
ESHRE Capri Workshop Group
Fertility and ageing
Hum. Reprod. Update, May 1, 2005; 11(3): 261 - 276.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
D. A. Gook, D.H. Edgar, J. Borg, J. Archer, and J.C. McBain
Diagnostic assessment of the developmental potential of human cryopreserved ovarian tissue from multiple patients using xenografting
Hum. Reprod., January 1, 2005; 20(1): 72 - 78.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
K. Lutchman Singh, M. Davies, and R. Chatterjee
Fertility in female cancer survivors: pathophysiology, preservation and the role of ovarian reserve testing
Hum. Reprod. Update, January 1, 2005; 11(1): 69 - 89.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
E. Tufan, K. Elter, and F. Durmusoglu
Assessment of reproductive ageing patterns by hormonal and ultrasonographic ovarian reserve tests
Hum. Reprod., November 1, 2004; 19(11): 2484 - 2489.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
F. Miro, S. W. Parker, L. J. Aspinall, J. Coley, P. W. Perry, and J. E. Ellis
Origins and Consequences of the Elongation of the Human Menstrual Cycle during the Menopausal Transition: The FREEDOM Study
J. Clin. Endocrinol. Metab., October 1, 2004; 89(10): 4910 - 4915.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
D. Nikolaou and C. Gilling-Smith
Early ovarian ageing: are women with polycystic ovaries protected?
Hum. Reprod., October 1, 2004; 19(10): 2175 - 2179.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
C. K. Welt, P. C. Smith, and A. E. Taylor
Evidence of Early Ovarian Aging in Fragile X Premutation Carriers
J. Clin. Endocrinol. Metab., September 1, 2004; 89(9): 4569 - 4574.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
J. Kline, A. Kinney, M.L. Reuss, A. Kelly, B. Levin, M. Ferin, and D. Warburton
Trisomic pregnancy and the oocyte pool
Hum. Reprod., July 1, 2004; 19(7): 1633 - 1643.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
W. H. Wallace and T. W. Kelsey
Ovarian reserve and reproductive age may be determined from measurement of ovarian volume by transvaginal sonography
Hum. Reprod., July 1, 2004; 19(7): 1612 - 1617.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
E. J. de Boer, I. Den Tonkelaar, C. W. Burger, C.W.N. Looman, F. E. van Leeuwen, E. R. te Velde, and on behalf of the OMEGA project group
The number of retrieved oocytes does not decrease during consecutive gonadotrophin-stimulated IVF cycles
Hum. Reprod., April 1, 2004; 19(4): 899 - 904.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
L.E. Bath, W.H.B. Wallace, M.P. Shaw, C. Fitzpatrick, and R.A. Anderson
Depletion of ovarian reserve in young women after treatment for cancer in childhood: detection by anti-Mullerian hormone, inhibin B and ovarian ultrasound
Hum. Reprod., November 1, 2003; 18(11): 2368 - 2374.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
R. A. Lobo
Early ovarian ageing: a hypothesis: What is early ovarian ageing?
Hum. Reprod., September 1, 2003; 18(9): 1762 - 1764.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
A. R. Baerwald, G. P. Adams, and R. A. Pierson
Characterization of Ovarian Follicular Wave Dynamics in Women
Biol Reprod, September 1, 2003; 69(3): 1023 - 1031.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
J. Kwee, M.W. Elting, R. Schats, P.D. Bezemer, C.B. Lambalk, and J. Schoemaker
Comparison of endocrine tests with respect to their predictive value on the outcome of ovarian hyperstimulation in IVF treatment: results of a prospective randomized study
Hum. Reprod., July 1, 2003; 18(7): 1422 - 1427.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
R. Lawson, T. El-Toukhy, A. Kassab, A. Taylor, P. Braude, J. Parsons, and P. Seed
Poor response to ovulation induction is a stronger predictor of early menopause than elevated basal FSH: a life table analysis
Hum. Reprod., March 1, 2003; 18(3): 527 - 533.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
P. Y.K. Yong, D. T. Baird, K.J. Thong, A. S. McNeilly, and R. A. Anderson
Prospective analysis of the relationships between the ovarian follicle cohort and basal FSH concentration, the inhibin response to exogenous FSH and ovarian follicle number at different stages of the normal menstrual cycle and after pituitary down-regulation
Hum. Reprod., January 1, 2003; 18(1): 35 - 44.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
N. Danilovich and M. R. Sairam
Haploinsufficiency of the Follicle-Stimulating Hormone Receptor Accelerates Oocyte Loss Inducing Early Reproductive Senescence and Biological Aging in Mice
Biol Reprod, August 1, 2002; 67(2): 361 - 369.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
M. Fukuda, K. Fukuda, C. Y. Andersen, and A. G. Byskov
Characteristics of human ovulation in natural cycles correlated with age and achievement of pregnancy
Hum. Reprod., December 1, 2001; 16(12): 2501 - 2507.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
L. E. Bath, R. A. Anderson, H. O.D. Critchley, C. J.H. Kelnar, and W.H. B. Wallace
Hypothalamic-pituitary-ovarian dysfunction after prepubertal chemotherapy and cranial irradiation for acute leukaemia
Hum. Reprod., September 1, 2001; 16(9): 1838 - 1844.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
D.M. Ranieri and P. Serhal
Ovarian reserve: A simple mathematical problem?
Hum. Reprod., June 1, 2000; 15(6): 1423 - 1424.
[Full Text] [PDF]

Home page
 Endocr. Rev.Home page
E. A. McGee and A. J. W. Hsueh
Initial and Cyclic Recruitment of Ovarian Follicles
Endocr. Rev., April 1, 2000; 21(2): 200 - 214.
[Abstract] [Full Text]

Home page
 Biol. Reprod.Home page
P. B. Miller, J. S. Charleston, D. E. Battaglia, N. A. Klein, and M. R. Soules
Morphometric Analysis of Primordial Follicle Number in Pigtailed Monkey Ovaries: Symmetry and Relationship with Age
Biol Reprod, August 1, 1999; 61(2): 553 - 556.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
C. K. Welt, D. J. McNicholl, A. E. Taylor, and J. E. Hall
Female Reproductive Aging Is Marked by Decreased Secretion of Dimeric Inhibin
J. Clin. Endocrinol. Metab., January 1, 1999; 84(1): 105 - 111.
[Abstract] [Full Text]

Home page
 Endocr. Rev.Home page
B. C. J. M. Fauser and A. M. van Heusden
Manipulation of Human Ovarian Function: Physiological Concepts and Clinical Consequences
Endocr. Rev., February 1, 1997; 18(1): 71 - 106.
[Abstract] [Full Text]

Home page
 Reproductive SciencesHome page
N. A. Klein, D. E. Battaglia, D. K. Clifron, W. J. Bremner, and M. R. Soules
The Gonadotropin Secretion Pattern in Normal Women of Advanced Reproductive Age in Relation to the Monotropic FSH Rise
Reproductive Sciences, January 1, 1996; 3(1): 27 - 32.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1994 by the Society for the Study of Reproduction.