Biol Reprod
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Dziadek, M.
Right arrow Articles by Chu, M. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dziadek, M.
Right arrow Articles by Chu, M. L.
Agricola
Right arrow Articles by Dziadek, M.
Right arrow Articles by Chu, M. L.

Biology of Reproduction, Vol 52, 885-894, Copyright © 1995 by Society for the Study of Reproduction

ARTICLES

Expression of collagen alpha 1(VI), alpha 2(VI), and alpha 3(VI) chains in the pregnant mouse uterus

M Dziadek, P Darling, RZ Zhang, TC Pan, E Tillet, R Timpl and ML Chu
Developmental Biology Research Group, Monash Medical Centre, Clayton, Victoria, Australia.

The alpha 1, alpha 2, and alpha 3 chains of collagen VI and mRNAs for these chains were localized in the female mouse reproductive tract by immunofluorescence and in situ hybridization. High levels of collagen VI protein and mRNAs were present in the endometrium and myometrium of the uterus up to Day 4.5 of pregnancy. After embryo implantation, reduction in collagen VI protein within the decidualizing endometrium correlated with significantly reduced steady-state levels of alpha 1(VI), alpha 2(VI), and alpha 3(VI) mRNAs, indicating either transcriptional down-regulation of collagen VI gene expression or decreased stability of transcripts. High levels of alpha 1(V1) and alpha 2(VI) mRNAs, but not alpha 3(VI) mRNA, in cells surrounding the uterine epithelium in the mesometrial region did not correlate with deposition of collagen VI protein in this region. These data are consistent with an important role of alpha 3(VI) in assembly of collagen VI heterotrimers. However, distinct immunostaining with antiserum to alpha 2(VI) chains in the extracellular matrix immediately beneath the uterine epithelium may indicate that alpha 2(VI) chains are deposited without the alpha 1(VI) or alpha 3(VI) collagen chains. No collagen VI protein or mRNAs were detected in any tissue layers of the embryo on Days 5.5 or 6.5 of gestation.


This article has been cited by other articles:


Home page
 J Mol EndocrinolHome page
J. Bailey, A. J Tyson-Capper, K. Gilmore, S. C Robson, and G N. Europe-Finner
Identification of human myometrial target genes of the cAMP pathway: the role of cAMP-response element binding (CREB) and modulator (CREM{alpha} and CREM{tau}2{alpha}) proteins
J. Mol. Endocrinol., February 1, 2005; 34(1): 1 - 17.
[Abstract] [Full Text] [PDF]

Home page
 J Mol EndocrinolHome page
J. Bailey and G N. Europe-Finner
Identification of human myometrial target genes of the c-Jun NH2-terminal kinase (JNK) pathway: the role of activating transcription factor 2 (ATF2) and a novel spliced isoform ATF2-small
J. Mol. Endocrinol., February 1, 2005; 34(1): 19 - 35.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
D. Docheva, E. B. Hunziker, R. Fassler, and O. Brandau
Tenomodulin Is Necessary for Tenocyte Proliferation and Tendon Maturation
Mol. Cell. Biol., January 15, 2005; 25(2): 699 - 705.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
H.-C. Keith Ho, K. E. McGrath, K. C. Brodbeck, J. Palis, and B. P. Schick
Serglycin Proteoglycan Synthesis in the Murine Uterine Decidua and Early Embryo
Biol Reprod, June 1, 2001; 64(6): 1667 - 1676.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1995 by the Society for the Study of Reproduction.