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Biology of Reproduction, Vol 54, 303-311, Copyright © 1996 by Society for the Study of Reproduction
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JF Strauss 3rd, F Martinez and M Kiriakidou
Department of Obstetrics and Gynecology University of Pennsylvania, Philadelphia 19104, USA.
Despite the amazing diversity of placental architecture across species, a number of common elements can be found, including the ability of all placentae to synthesize and metabolize steroid hormones; the assignment of steroidogenic activities to specific trophoblast phenotypes; the use of novel mechanisms to control expression of steroidogenic enzyme genes, which differ from those employed in the adrenal cortex and gonads; and interactions with the maternal and fetal compartments encompassing supply of steroid hormone precursors as well as regulatory influences of maternal ovarian and pituitary hormones and fetal adrenal cortical steroids.
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