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Biology of Reproduction, Vol 54, 554-562, Copyright © 1996 by Society for the Study of Reproduction

REVIEWS

Tumor necrosis factors: pivotal components of pregnancy?

JS Hunt, HL Chen and L Miller
Department of Anatomy, University of Kansas Medical Center, Kansas City 66160-7400, USA. jhunt@kumc.wpo.ukans.edu

Tumor necrosis factor alpha is a major component of the infection- stimulated cytokine milieux associated with preterm labor and pregnancy termination. As a consequence, this potent factor is thought by some to have exclusively negative effects on the course of pregnancy. Yet in humans and other mammals, messenger RNA hybridizing with tumor necrosis factor alpha cRNA probes and protein detected by anti-tumor necrosis factor alpha have been identified in normal cycling and pregnant uteri, placentas, and embryos, consistent with an important role for tumor necrosis factor in female reproduction and embryonic development. Here, evidence for this intriguing dichotomy is presented, unresolved aspects are discussed, and potential roles for uteroplacental and embryonic tumor necrosis factor are proposed.




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Copyright © 1996 by the Society for the Study of Reproduction.