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Biology of Reproduction, Vol 56, 569-574, Copyright © 1997 by Society for the Study of Reproduction
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S Meizel
Department of Cell Biology and Human Anatomy, University of California School of Medicine, Davis 95616-8643, USA. smeizel@ucdavis.edu
Two different amino acid neurotransmitter receptor/Cl-channels, a gamma- aminobutyric acid (GABA) receptor-like/Cl- channel and a glycine receptor/Cl- channel, have recently been found in mammalian sperm and shown to be involved in the sperm acrosome reaction (AR), an exocytotic event essential to mammalian fertilization. The identity of the receptor/channel involved in the AR depends upon the stimulatory ligand. The AR initiated by the egg zona pellucida requires the participation of the sperm glycine receptor/Cl- channel, whereas the AR initiated by another putative physiological AR initiator, progesterone, involves the sperm GABA receptor-like/Cl- channel. Cl- efflux through the latter has been shown to occur during the progesterone-initiated AR. Activation of sperm amino acid neurotransmitter receptor/Cl- channels may result in plasma membrane depolarization and thereby exert at least a partial control over voltage-sensitive sperm Ca2+ channels and Ca2+ influx important to the AR.
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