| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Biology of Reproduction, Vol 57, 1338-1345, Copyright © 1997 by Society for the Study of Reproduction
ARTICLES |
HS Taylor, GB Vanden Heuvel and P Igarashi
Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520, USA. hugh.taylor@yale.edu
The mammalian female reproductive system arises from the uniform paramesonephric duct. The molecular mechanisms that establish differential development along this axis are unknown. We determined the pattern and timing of genes of the Hoxa axis in the development of the Mullerian tract. Hoxa-9, Hoxa-10, Hoxa-11, and Hoxa-13 are all expressed along the length of the paramesonephric duct in the embryonic mouse. After birth, a spatial Hox axis is established, corresponding to the postnatal differentiation of this organ system in the mouse. Hoxa-9 is expressed in the fallopian tubes, Hoxa-10 in the uterus, Hoxa-11 in the uterus and uterine cervix, and Hoxa-13 in the upper vagina. This expression pattern follows the paradigm of spatial colinearity but is a novel exception to temporal colinearity that has been considered typical of Hox genes. These genes remain expressed in the adult mouse and are expressed in the same pattern in the human. The female reproductive system undergoes dramatic structural and functional changes during the estrous cycle and in pregnancy, retaining a high degree of developmental plasticity. The late establishment of a Hox axis and persistent expression of Hox genes in the adult may play an important role in preserving this plasticity.
This article has been cited by other articles:
|
|
 |
|
  A. K. Nagaraja, C. Andreu-Vieyra, H. L. Franco, L. Ma, R. Chen, D. Y. Han, H. Zhu, J. E. Agno, P. H. Gunaratne, F. J. DeMayo, et al. Deletion of Dicer in Somatic Cells of the Female Reproductive Tract Causes Sterility Mol. Endocrinol., October 1, 2008; 22(10): 2336 - 2352. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W.-F. Shen, Y.-L. Hu, L. Uttarwar, E. Passegue, and C. Largman MicroRNA-126 Regulates HOXA9 by Binding to the Homeobox Mol. Cell. Biol., July 15, 2008; 28(14): 4609 - 4619. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Xu, D. Geerts, K. Qian, H. Zhang, and G. Zhu Myeloid ecotropic viral integration site 1 (MEIS) 1 involvement in embryonic implantation Hum. Reprod., June 1, 2008; 23(6): 1394 - 1406. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Vitiello, R. Pinard, and H. S. Taylor Gene Expression Profiling Reveals Putative HOXA10 Downstream Targets in the Periimplantation Mouse Uterus Reproductive Sciences, May 1, 2008; 15(5): 529 - 535. [Abstract] [PDF]
|
|
|
|
 |
|
 S. M Blois, U. Kammerer, C. A. Soto, M. C Tometten, V. Shaikly, G. Barrientos, R. Jurd, D. Rukavina, A. W Thomson, B. F Klapp, et al. Dendritic Cells: Key to Fetal Tolerance? Biol Reprod, October 1, 2007; 77(4): 590 - 598. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Ota, C. Blake Gilks, T. Longacre, P. C. K. Leung, and N. Auersperg HOXA7 in Epithelial Ovarian Cancer: Interrelationships Between Differentiation and Clinical Features Reproductive Sciences, September 1, 2007; 14(6): 605 - 614. [Abstract] [PDF]
|
|
|
|
 |
|
 R. Martin, M. B. Taylor, G. Krikun, C. Lockwood, G. E. Akbas, and H. S. Taylor Differential Cell-Specific Modulation of HOXA10 by Estrogen and Specificity Protein 1 Response Elements J. Clin. Endocrinol. Metab., May 1, 2007; 92(5): 1920 - 1926. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Suzuki, H. Urushitani, T. Sato, T. Kobayashi, H. Watanabe, Y. Ohta, and T. Iguchi Gene Expression Change in the Mullerian Duct of the Mouse Fetus Exposed to Diethylstilbestrol In Utero Experimental Biology and Medicine, April 1, 2007; 232(4): 503 - 514. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. E. Akbas, X. Fei, and H. S. Taylor Regulation of HOXA10 expression by phytoestrogens Am J Physiol Endocrinol Metab, February 1, 2007; 292(2): E435 - E442. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. C. Smith and H. S. Taylor Xenoestrogen exposure imprints expression of genes (Hoxa10) required for normal uterine development FASEB J, January 1, 2007; 21(1): 239 - 246. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. P. Herring, O. El-Mounayri, P. J. Gallagher, F. Yin, and J. Zhou Regulation of myosin light chain kinase and telokin expression in smooth muscle tissues Am J Physiol Cell Physiol, November 1, 2006; 291(5): C817 - C827. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ulukus, H. Cakmak, and A. Arici The Role of Endometrium in Endometriosis Reproductive Sciences, October 1, 2006; 13(7): 467 - 476. [Abstract] [PDF]
|
|
|
|
|
|
Y. Yin, C. Lin, and L. Ma Msx2 Promotes Vaginal Epithelial Differentiation and Wolffian Duct Regression and Dampens the Vaginal Response to Diethylstilbestrol Mol. Endocrinol., July 1, 2006; 20(7): 1535 - 1546. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. S. Daftary and H. S. Taylor Endocrine Regulation of HOX Genes Endocr. Rev., June 1, 2006; 27(4): 331 - 355. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. S. Taylor and X. Fei Emx2 Regulates Mammalian Reproduction by Altering Endometrial Cell Proliferation Mol. Endocrinol., November 1, 2005; 19(11): 2839 - 2846. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Seli, U. A. Kayisli, H. Cakmak, O. Bukulmez, I. Bildirici, O. Guzeloglu-Kayisli, and A. Arici Removal of hydrosalpinges increases endometrial leukaemia inhibitory factor (LIF) expression at the time of the implantation window Hum. Reprod., November 1, 2005; 20(11): 3012 - 3017. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Du, G. S. Daftary, S. I. Lalwani, and H. S. Taylor Direct Regulation of HOXA10 by 1,25-(OH)2D3 in Human Myelomonocytic Cells and Human Endometrial Stromal Cells Mol. Endocrinol., September 1, 2005; 19(9): 2222 - 2233. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Fei, H. Chung, and H. S. Taylor Methoxychlor Disrupts Uterine Hoxa10 Gene Expression Endocrinology, August 1, 2005; 146(8): 3445 - 3451. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Yin and L. Ma Development of the Mammalian Female Reproductive Tract J. Biochem., June 1, 2005; 137(6): 677 - 683. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Sarno, H. J. Kliman, and H. S. Taylor HOXA10, Pbx2, and Meis1 Protein Expression in the Human Endometrium: Formation of Multimeric Complexes on HOXA10 Target Genes J. Clin. Endocrinol. Metab., January 1, 2005; 90(1): 522 - 528. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Y Lee and F. J DeMayo Animal models of implantation Reproduction, December 1, 2004; 128(6): 679 - 695. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. S. Daftary and H. S. Taylor EMX2 Gene Expression in the Female Reproductive Tract and Aberrant Expression in the Endometrium of Patients with Endometriosis J. Clin. Endocrinol. Metab., May 1, 2004; 89(5): 2390 - 2396. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Mericskay, J. Kitajewski, and D. Sassoon Wnt5a is required for proper epithelial-mesenchymal interactions in the uterus Development, May 1, 2004; 131(9): 2061 - 2072. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. H. H. Wong, H. D. Wintch, and M. R. Capecchi Hoxa11 Regulates Stromal Cell Death and Proliferation during Neonatal Uterine Development Mol. Endocrinol., January 1, 2004; 18(1): 184 - 193. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. E. Akbas and H. S. Taylor HOXC and HOXD Gene Expression in Human Endometrium: Lack of Redundancy with HOXA Paralogs Biol Reprod, January 1, 2004; 70(1): 39 - 45. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. P. Whitcomb, D. G. Mutch, T. J. Herzog, J. S. Rader, R. K. Gibb, and P. J. Goodfellow Frequent HOXA11 and THBS2 Promoter Methylation, and a Methylator Phenotype in Endometrial Adenocarcinoma Clin. Cancer Res., June 1, 2003; 9(6): 2277 - 2287. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.J. Buck, R.M. Williams, I.A. Hughes, and C.L. Acerini In-utero androgen exposure and 2nd to 4th digit length ratio--comparisons between healthy controls and females with classical congenital adrenal hyperplasia Hum. Reprod., May 1, 2003; 18(5): 976 - 979. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. Troy, G. S. Daftary, C. N. Bagot, and H. S. Taylor Transcriptional Repression of Peri-Implantation EMX2 Expression in Mammalian Reproduction by HOXA10 Mol. Cell. Biol., January 1, 2003; 23(1): 1 - 13. [Abstract] [Full Text]
|
|
|
|
|
|
D. Cermik, B. Selam, and H. S. Taylor Regulation of HOXA-10 Expression by Testosterone in Vitro and in the Endometrium of Patients with Polycystic Ovary Syndrome J. Clin. Endocrinol. Metab., January 1, 2003; 88(1): 238 - 243. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Kim, H. S. Taylor, G. E. Akbas, I. Foucher, A. Trembleau, R. C. Jaffe, A. T. Fazleabas, and T. G. Unterman Regulation of Insulin-Like Growth Factor Binding Protein-1 Promoter Activity by FKHR and HOXA10 in Primate Endometrial Cells Biol Reprod, January 1, 2003; 68(1): 24 - 30. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. M. Chau, S. Pando, and H. S. Taylor HOXA11 Silencing and Endogenous HOXA11 Antisense Ribonucleic Acid in the Uterine Endometrium J. Clin. Endocrinol. Metab., June 1, 2002; 87(6): 2674 - 2680. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. S. Daftary, P. J. Troy, C. N. Bagot, S. L. Young, and H. S. Taylor Direct Regulation of {beta}3-Integrin Subunit Gene Expression by HOXA10 in Endometrial Cells Mol. Endocrinol., March 1, 2002; 16(3): 571 - 579. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Zhao and S. S. Potter Functional specificity of the Hoxa13 homeobox Development, August 15, 2001; 128(16): 3197 - 3207. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Cermik, M. Karaca, and H. S. Taylor HOXA10 Expression Is Repressed by Progesterone in the Myometrium: Differential Tissue-Specific Regulation of HOX Gene Expression in the Reproductive Tract J. Clin. Endocrinol. Metab., July 1, 2001; 86(7): 3387 - 3392. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. T. MacLaughlin, J. Teixeira, and P. K. Donahoe Perspective: Reproductive Tract Development--New Discoveries and Future Directions Endocrinology, June 1, 2001; 142(6): 2167 - 2172. [Full Text] [PDF]
|
|
|
|
 |
|
 B. Nait–Oumesmar, A. B. Copperman, and R. A. Lazzarini Placental Expression and Chromosomal Localization of the Human Gcm 1 Gene J. Histochem. Cytochem., July 1, 2000; 48(7): 915 - 922. [Abstract] [Full Text]
|
|
|
|
|
|
K. BLOCK, A. KARDANA, P. IGARASHI, and H. S. TAYLOR In utero diethylstilbestrol (DES) exposure alters Hox gene expression in the developing mullerian system FASEB J, June 1, 2000; 14(9): 1101 - 1108. [Abstract] [Full Text]
|
|
|
|
 |
|
 K. J. Peterson and E. H. Davidson Special Feature: Regulatory evolution and the origin of the bilaterians PNAS, April 25, 2000; 97(9): 4430 - 4433. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. C. Post and J. W. Innis Infertility in Adult Hypodactyly Mice Is Associated with Hypoplasia of Distal Reproductive Structures Biol Reprod, December 1, 1999; 61(6): 1402 - 1408. [Abstract] [Full Text]
|
|
|
|
|
|
H. S. Taylor, C. Bagot, A. Kardana, D. Olive, and A. Arici HOX gene expression is altered in the endometrium of women with endometriosis Hum. Reprod., May 1, 1999; 14(5): 1328 - 1331. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. S. Taylor, P. Igarashi, D. L. Olive, and A. Arici Sex Steroids Mediate HOXA11 Expression in the Human Peri-Implantation Endometrium J. Clin. Endocrinol. Metab., March 1, 1999; 84(3): 1129 - 1135. [Abstract] [Full Text]
|
|
|
|
|
|
C Miller and D. Sassoon Wnt-7a maintains appropriate uterine patterning during the development of the mouse female reproductive tract Development, January 8, 1998; 125(16): 3201 - 3211. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
