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Biology of Reproduction, Vol 58, 1065-1070, Copyright © 1998 by Society for the Study of Reproduction

ARTICLES

Fetal and maternal endocrine changes approaching parturition in the goat: lack of evidence for prostaglandins E2 and F2alpha as signals for luteolysis

MM Ford, IR Young, DJ Caddy and GD Thorburn
Department of Physiology, Monash University, Clayton, Victoria, Australia.

We investigated the temporal relationship of fetal cortisol secretion to circulating concentrations of fetal ACTH1-39 and its high-molecular weight precursors in goats. We also measured the concentrations of progesterone, estradiol-17beta estrone sulfate, prostaglandin (PG) E, PGF2alpha, and PGF2alpha metabolite (PGFM) in maternal arterial plasma over the last month of gestation. Prostaglandin concentrations were also measured in utero-ovarian venous plasma. There was a positive association between ACTH1-39 in fetal plasma and the prepartum surge in fetal cortisol that commenced 8 days before labor. The fetal cortisol surge was followed by a simultaneous decrease in maternal progesterone and an increase in plasma estrogens commencing 3-4 days before labor. No change in basal prostaglandin concentration occurred before this time. There was a positive veno-arterial difference of PGE and PGF2alpha across the uterine vascular bed, confirming the uteroplacental unit as a major source of these eicosanoids in the plasma of the pregnant doe. We conclude that the fetal signal for parturition precedes luteolysis by some 5 days and find no evidence of changes in the basal concentrations of PGE and PGF2alpha in maternal plasma at the time of luteolysis.


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M.M. Ford, G.D. Thorburn, D.J. Caddy, and I.R. Young
Pulsatile Output of Prostaglandin F2{alpha} Does Not Increase Around the Time of Luteolysis in the Pregnant Goat
Biol Reprod, August 1, 1999; 61(2): 411 - 415.
[Abstract] [Full Text]

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 Physiol. Rev.Home page
J. A. McCracken, E. E. Custer, and J. C. Lamsa
Luteolysis: A Neuroendocrine-Mediated Event
Physiol Rev, April 1, 1999; 79(2): 263 - 323.
[Abstract] [Full Text] [PDF]


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Copyright © 1998 by the Society for the Study of Reproduction.