| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Biology of Reproduction, Vol 58, 875-879, Copyright © 1998 by Society for the Study of Reproduction
ARTICLES |
RC Gouge, P Marshburn, BE Gordon, W Nunley and YM Huet-Hudson
Department of Biology, University of North Carolina at Charlotte, 28223, USA.
The role of nitric oxide (NO) in activation of cGMP is well established. It has been proposed that the ratio of cAMP to cGMP may be important in the regulation of preimplantation embryonic growth and differentiation. Therefore, we determined the ability of murine preimplantation embryos to produce NO. In addition, NO as an endogenous smooth muscle relaxant and vasodilator is a candidate for involvement in embryo implantation because this process requires increased vascular permeability and uterine quiescence at the sites of blastocyst apposition. Nitrite assays, an indirect measure of NO production, indicate that preimplantation murine embryos produce NO. This production was reversibly inhibited by culture of embryos in medium containing a nonspecific NO synthase (NOS) inhibitor (NG-nitro-L- arginine). Additionally, inhibition of normal development was observed in embryos cultured with NOS inhibitor. NO levels increased in culture medium when ovariectomized progesterone-treated animals were exposed to estrogen for 1 h in utero. Such hormonal treatment induces implantation. These data indicate that NO levels are regulated by estrogen and may be important in regulation of implantation. In addition, these data demonstrate for the first time that NO production appears to be required for normal embryonic development.
This article has been cited by other articles:
|
|
 |
|
  P. Pallares, R. A Garcia-Fernandez, L. M Criado, C. A Letelier, D. Esteban, J. M Fernandez-Toro, J. M Flores, and A. Gonzalez-Bulnes Disruption of the endothelial nitric oxide synthase gene affects ovulation, fertilization and early embryo survival in a knockout mouse model Reproduction, November 1, 2008; 136(5): 573 - 579. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Zeng, F. Wang, X. Fan, W. Yang, B. Zhou, P. Li, Y. Yin, G. Wu, and J. Wang Dietary Arginine Supplementation during Early Pregnancy Enhances Embryonic Survival in Rats J. Nutr., August 1, 2008; 138(8): 1421 - 1425. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Pallares and A. Gonzalez-Bulnes Intrauterine Growth Retardation in Endothelial Nitric Oxide Synthase-Deficient Mice Is Established from Early Stages of Pregnancy Biol Reprod, June 1, 2008; 78(6): 1002 - 1006. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Pacher, J. S. Beckman, and L. Liaudet Nitric Oxide and Peroxynitrite in Health and Disease Physiol Rev, January 1, 2007; 87(1): 315 - 424. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Allen, S. Buttner, A. D. Aragon, J. A. Thomas, O. Meirelles, J. E. Jaetao, D. Benn, S. W. Ruby, M. Veenhuis, F. Madeo, et al. Isolation of quiescent and nonquiescent cells from yeast stationary-phase cultures J. Cell Biol., July 3, 2006; 174(1): 89 - 100. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. C. Manser and F. D. Houghton Ca2+-linked upregulation and mitochondrial production of nitric oxide in the mouse preimplantation embryo J. Cell Sci., May 15, 2006; 119(10): 2048 - 2055. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Sengupta, L. Dhawan, P G L Lalitkumar, and D Ghosh Nitric oxide in blastocyst implantation in the rhesus monkey Reproduction, September 1, 2005; 130(3): 321 - 332. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R.C. Manser, H.J. Leese, and F.D. Houghton Effect of Inhibiting Nitric Oxide Production on Mouse Preimplantation Embryo Development and Metabolism Biol Reprod, August 1, 2004; 71(2): 528 - 533. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. K. Nath, J. Enciso, M. Kuniyasu, X.-Y. Hao, J. A. Madri, and E. Pinter Nitric oxide modulates murine yolk sac vasculogenesis and rescues glucose induced vasculopathy Development, May 15, 2004; 131(10): 2485 - 2496. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Holmqvist, B. Ellingsen, J. Forsell, I. Zhdanova, and P. Alm The early ontogeny of neuronal nitric oxide synthase systems in the zebrafish J. Exp. Biol., February 22, 2004; 207(6): 923 - 935. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. M. Martin, A. E. Sutherland, and L. J. Van Winkle Amino Acid Transport Regulates Blastocyst Implantation Biol Reprod, October 1, 2003; 69(4): 1101 - 1108. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Tranguch, N. Steuerwald, and Y. M. Huet-Hudson Nitric Oxide Synthase Production and Nitric Oxide Regulation of Preimplantation Embryo Development Biol Reprod, May 1, 2003; 68(5): 1538 - 1544. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Dinara, K. Sengoku, K. Tamate, M. Horikawa, and M. Ishikawa Effects of supplementation with free radical scavengers on the survival and fertilization rates of mouse cryopreserved oocytes Hum. Reprod., September 1, 2001; 16(9): 1976 - 1981. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H.-Y. Li, S.-P. Chang, C.-C. Yuan, H.-T. Chao, H.-T. Ng, and Y.-J. Sung Nitric oxide induces extensive apoptosis in endometrial epithelial cells in the presence of progesterone: involvement of mitogen-activated protein kinase pathways Mol. Hum. Reprod., August 1, 2001; 7(8): 755 - 763. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. J. Van Winkle Amino Acid Transport Regulation and Early Embryo Development Biol Reprod, January 1, 2001; 64(1): 1 - 12. [Abstract] [Full Text]
|
|
|
|
 |
|
 R. Fritsche, T. Schwerte, and B. Pelster Nitric oxide and vascular reactivity in developing zebrafish, Danio rerio Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2000; 279(6): R2200 - R2207. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Gagioti, C. Scavone, and E. Bevilacqua Participation of the Mouse Implanting Trophoblast in Nitric Oxide Production During Pregnancy Biol Reprod, February 1, 2000; 62(2): 260 - 268. [Abstract] [Full Text]
|
|
|
|
 |
|
 W Bloch, B.K Fleischmann, D.E Lorke, C Andressen, B Hops, J Hescheler, and K Addicks Nitric oxide synthase expression and role during cardiomyogenesis Cardiovasc Res, August 15, 1999; 43(3): 675 - 684. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Jae Chung, W. Dong Zhao, and N. Wakasugi Participation of Embryonic Genotype in the Pregnancy Block Phenomenon in Mice Biol Reprod, August 1, 1999; 61(2): 367 - 371. [Abstract] [Full Text]
|
|
|
|
|
|
A. Nishikimi, J. Mukai, and M. Yamada Nuclear Translocation of Nuclear Factor Kappa B in Early 1-Cell Mouse Embryos Biol Reprod, June 1, 1999; 60(6): 1536 - 1541. [Abstract] [Full Text]
|
|
|
|
|
|
T.L. Purcell, R. Given, K Chwalisz, and R.E. Garfield Nitric oxide synthase distribution during implantation in the mouse Mol. Hum. Reprod., May 1, 1999; 5(5): 467 - 475. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. C. Dunnam, M. J. Hill, D. M. Lawson, and J. C. Dunbar Ovarian Hormone Secretory Response to Gonadotropins and Nitric Oxide Following Chronic Nitric Oxide Deficiency in the Rat Biol Reprod, April 1, 1999; 60(4): 959 - 963. [Abstract] [Full Text]
|
|
|
|
 |
|
 G. J. JI, B. K. FLEISCHMANN, W. BLOCH, M. FEELISCH, C. ANDRESSEN, K. ADDICKS, and J. HESCHELER Regulation of the L-type Ca2+ channel during cardiomyogenesis: switch from NO to adenylyl cyclase-mediated inhibition FASEB J, February 1, 1999; 13(2): 313 - 324. [Abstract] [Full Text]
|
|
|
|
|
|
K. Chwalisz, E. Winterhager, T. Thienel, and R. E. Garfield Synergistic role of nitric oxide and progesterone during the establishment of pregnancy in the rat* Hum. Reprod., February 1, 1999; 14(2): 542 - 552. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Wu, W. G. Pond, S. P. Flynn, T. L. Ott, and F. W. Bazer Maternal Dietary Protein Deficiency Decreases Nitric Oxide Synthase and Ornithine Decarboxylase Activities in Placenta and Endometrium of Pigs During Early Gestation J. Nutr., December 1, 1998; 128(12): 2395 - 2402. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
