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Biology of Reproduction 59, 124-130 (1998)
©Copyright 1998 Society for the Study of Reproduction, Inc.

Estradiol Increases Relative Amounts of Insulin-Like Growth Factor Binding Protein (IGFBP)-3 in Serum and Expression of IGFBP-2 in Anterior Pituitaries of Ewes1

J.A. Clapper3,a, J.L. Snydera, A.J. Robertsb, D.L. Hamernik4,c, , and G.E. Moss2,a

a University of Wyoming, Department of Animal Science, Laramie, b Wyoming 82071 USDA, Agricultural Research Service, R.L. Hruska U.S. Meat Animal Research Center, Clay Center, Nebraska 68933 c University of Arizona, Department of Physiology, Tucson, Arizona 85718

This study determined whether estradiol regulates insulin-like growth factor (IGF)-I and IGF binding proteins (IGFBPs) in the pituitary gland, hypophyseal stalk median eminence (SME), and circulation concomitantly with effects on LH. Ovariectomized ewes received an estradiol implant or no implant during the anestrous season and were slaughtered 80 days later. Estradiol suppressed serum LH to a greater extent during anestrus than after onset of the breeding season (Days 60 and 75). Amounts of mRNA for LHß subunit were decreased by estradiol, but mRNA for {alpha} and FSHß subunits were not affected. Estradiol increased serum IGF-I, IGFBP-3, and IGFBP-4 throughout the treatment period, but it did not influence other IGFBPs in serum. In response to estradiol, pituitary IGFBP-2 tended to increase and mRNA for IGFBP-2 increased twofold. Other IGFBPs in the pituitary gland were not influenced by estradiol. In the SME, IGFBP-2, IGFBP-5, and the 40-kDa IGFBP-3 were increased by estradiol. Thus, estradiol influences both the IGF and gonadotropin systems in sheep. Estradiol influences on gonadotroph function may be mediated by alterations in the IGF system.

1 This work was supported by a grant from the USDA NRICGP to G.E.M. (#9401472). Mention of trade names is necessary to report factually on available data; however, the USDA neither guarantees nor warrants the standard of the product, and the use of the name by USDA implies no approval of the product to the exclusion of others that may also be suitable. Presented in part at the 88th meeting of the American Society of Animal Science, Rapid City, SD.

2 Correspondence: Gary E. Moss, University of Wyoming, Department of Animal Science, P.O. Box 3684, Laramie, WY 82071. FAX: (307) 766–2355; gm{at}uwyo.edu

3 Current address: Department of Animal & Range Sciences, South Dakota State University, Brookings, SD 57007.

4 Current address: USDA-CSREES-NRI, 1400 Independence Ave SW, Stop 2241, Washington, DC 20250–2241.




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