Biol Reprod
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Adams, M. L.
Right arrow Articles by Cicero, T. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Adams, M. L.
Right arrow Articles by Cicero, T. J.
Agricola
Right arrow Articles by Adams, M. L.
Right arrow Articles by Cicero, T. J.
Biology of Reproduction 59, 248-254 (1998)
©Copyright 1998 Society for the Study of Reproduction, Inc.

Imidazoles Suppress Rat Testosterone Secretion and Testicular Interstitial Fluid Formation In Vivo1

Michael L. Adams2,a, Edward R. Meyera, , and Theodore J. Ciceroa

a Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri 63110–1093

The aim of these studies was to examine the effects of imidazoles on testosterone secretion and testicular interstitial fluid (TIF) formation through measurement of serum LH, serum testosterone, TIF testosterone, and TIF volumes. Imidazole, 1-methylimidazole, 4-methylimidazole (4-MI), and ketoconazole, an oral imidazole antifungal agent, caused dose-dependent decreases in testosterone secretion and TIF formation. Imidazole, 2-methylimidazole, and 4-MI decreased LH secretion. 4-MI decreased testosterone secretion 1–6 h after injection, increased testosterone at 8–16 h, decreased LH secretion at 4 h, decreased TIF volumes at 1–8 h, and slightly increased TIF volumes at 24 h. 4-MI blocked the stimulatory effects of hCG on testosterone secretion and prevented an expected increase in LH secretion after the 4-MI-induced decrease in testosterone secretion. 4-MI also reversed the effects of three other stimulants of testosterone secretion that presumably act through three different testicular regulatory systems: N-methyl-D,L-aspartate, an excitatory amino acid; NG-nitro-L-arginine methyl ester, a nitric oxide synthase inhibitor; and naltrexone, an opioid antagonist. These results support the hypothesis that imidazoles inhibit testicular function and male reproductive function through inhibition of testosterone secretion, TIF formation, and LH secretion regulatory systems.

1 This work was supported by grants AA-09222, AA-07144, and AA-07466 from the National Institute on Alcohol Abuse and Alcoholism and DA-03833 from the National Institute on Drug Abuse. T.J.C. is the recipient of a Research Scientist Award (DA-00095) from the National Institute on Drug Abuse.

2 Correspondence: Michael L. Adams, Department of Psychiatry, Box 8134, Washington University School of Medicine, 4940 Children's Place, St. Louis, MO 63110–1093. FAX: (314) 747–2163; mike-a{at}dcm.wustl.edu




This article has been cited by other articles:


Home page
 Toxicol PatholHome page
Y. Tani, P. M. Foster, R. C. Sills, P. C. Chan, S. D. Peddada, and A. Nyska
Epididymal Sperm Granuloma Induced by Chronic Administration of 2-Methylimidazole in B6C3F1 Mice
Toxicol Pathol, April 1, 2005; 33(3): 313 - 319.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1998 by the Society for the Study of Reproduction.