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Biology of Reproduction 59, 326-329 (1998)
©Copyright 1998 Society for the Study of Reproduction, Inc.

Modulation of 72-Kilodalton Type IV Collagenase (Matrix Metalloproteinase-2) by Ascorbic Acid in Cultured Human Amnion-Derived Cells1

Frania Pfefferc, Esther Casanuevac, Jacobo Kamard, Alejandra Guerrad, Otilia Perichartd, , and Felipe Vadillo-Ortega2,d

c Nutrition Research Department, d Instituto Nacional de Perinatologia and Departamento de Biologia de la Reproduccion, Instituto Nacional de la Nutricion "Salvador Zubiran," 14000 Mexico, D.F., Mexico

Extensive research has been done to investigate the effects of nutrients on placental and fetal development. It is now evident that environmental factors such as diet may exert a profound effect on gene expression during pregnancy. A low intake of vitamin C during pregnancy has been linked to a higher risk of premature rupture of the membranes (PROM) because of its well-known role in collagen biosynthesis. Here we report a new effect of ascorbic acid acting as a modulator of the 72-kDa type IV collagenase (matrix metalloproteinase-2; MMP-2). MMP-2 expression/activity is down-regulated by vitamin C in human amnion cultured cells. The regulatory effect is exerted at the transcriptional level and is specific for MMP-2. Matrix metalloproteinases are implicated in tissue remodeling, and our results allow us to suggest a molecular mechanism that relates poor availability of vitamin C during pregnancy and the development of PROM.

1 This study was supported by CONACyT (Mexico) grants 3511M and 783P-M.

2 Correspondence: Felipe Vadillo-Ortega, Instituto Nacional de la Nutricion "Salvador Zubiran," Departamento de Biologia de la Reproduccion, Vasco de Quiroga 15, Tlalpan, Mexico, D.F., 14000, Mexico. FAX: (525)6559859; 74173.2113{at}compuserve.com




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Copyright © 1998 by the Society for the Study of Reproduction.