| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
a Department of Animal & Range Sciences,
b and Cell Biology Center, Biotechnology Institute, North Dakota State University, Fargo, North Dakota 58105
Uterine expression of angiogenic factors (vascular endothelial growth factor [VEGF] and basic fibroblast growth factor [bFGF]) was evaluated in ovariectomized ewes at 0, 2, 4, 8, 24, 48, or 72 h after estradiol (E2) treatment. Endometrial VEGF mRNA increased more than 5-fold from 0 to 4 h, remained elevated at 8 h, and then declined through 72 h after E2 treatment. In contrast, endometrial bFGF mRNA remained constant from 0 to 4 h, increased 2.2-fold from 4 to 8 h, remained elevated at 24 h, and then declined through 72 h. Immunostaining for VEGF was present in myometrial and endometrial microvessels (arterioles, venules, and/or capillaries) and also in myometrial smooth muscle; the pattern of VEGF immunostaining followed that of mRNA expression, being elevated at 4 and 8 h after E2 treatment. Immunostaining for bFGF was present exclusively in uterine glands; the pattern of bFGF immunostaining also followed that of its mRNA, being elevated at 8 and 24 h after E2. On the basis of these observations, we suggest that VEGF and bFGF are probably important factors responsible for the dramatic uterine microvascular response that occurs 8 to 24 h after E2 treatment in ovariectomized ewes.
2 Correspondence. FAX: (701) 231–7590; lreynold{at}prairie.nodak.edu
This article has been cited by other articles:
|
|
 |
|
  M. R. O'Neil, G. P. Lardy, L. P. Reynolds, J. S. Caton, and K. A. Vonnahme Impacts of linseed meal and estradiol-17{beta} on mass, cellularity, angiogenic factors, and vascularity of the jejunum J Anim Sci, November 1, 2008; 86(11): 3014 - 3022. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. W. Bonagura, G. J. Pepe, A. C. Enders, and E. D. Albrecht Suppression of Extravillous Trophoblast Vascular Endothelial Growth Factor Expression and Uterine Spiral Artery Invasion by Estrogen during Early Baboon Pregnancy Endocrinology, October 1, 2008; 149(10): 5078 - 5087. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. E. Echternkamp, K. A. Vonnahme, J. A. Green, and S. P. Ford Increased vascular endothelial growth factor and pregnancy-associated glycoproteins, but not insulin-like growth factor-I, in maternal blood of cows gestating twin fetuses J Anim Sci, August 1, 2006; 84(8): 2057 - 2064. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. D. Michael, I. M. Alvarez, O. M. Ocon, A. M. Powell, N. C. Talbot, S. E. Johnson, and A. D. Ealy Fibroblast Growth Factor-2 Is Expressed by the Bovine Uterus and Stimulates Interferon-{tau} Production in Bovine Trophectoderm Endocrinology, July 1, 2006; 147(7): 3571 - 3579. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Cotton, G. M. Gibbs, L. G. Sanchez-Partida, J. R. Morrison, D. M. de Kretser, and M. K. O'Bryan FGFR-1 signaling is involved in spermiogenesis and sperm capacitation J. Cell Sci., January 1, 2006; 119(1): 75 - 84. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. R. Magness, T. M. Phernetton, T. C. Gibson, and D.-b. Chen Uterine blood flow responses to ICI 182 780 in ovariectomized oestradiol-17{beta}-treated, intact follicular and pregnant sheep J. Physiol., May 15, 2005; 565(1): 71 - 83. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A. Redmer, R. P. Aitken, J. S. Milne, L. P. Reynolds, and J. M. Wallace Influence of Maternal Nutrition on Messenger RNA Expression of Placental Angiogenic Factors and Their Receptors at Midgestation in Adolescent Sheep Biol Reprod, April 1, 2005; 72(4): 1004 - 1009. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Y Lee and F. J DeMayo Animal models of implantation Reproduction, December 1, 2004; 128(6): 679 - 695. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. D. Albrecht, V. A. Robb, and G. J. Pepe Regulation of Placental Vascular Endothelial Growth/Permeability Factor Expression and Angiogenesis by Estrogen during Early Baboon Pregnancy J. Clin. Endocrinol. Metab., November 1, 2004; 89(11): 5803 - 5809. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. A. Robb, G. J. Pepe, and E. D. Albrecht Acute Temporal Regulation of Placental Vascular Endothelial Growth/Permeability Factor Expression in Baboons by Estrogen Biol Reprod, November 1, 2004; 71(5): 1694 - 1698. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Vonnahme and S. P. Ford Differential Expression of the Vascular Endothelial Growth Factor-Receptor System in the Gravid Uterus of Yorkshire and Meishan Pigs Biol Reprod, July 1, 2004; 71(1): 163 - 169. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. D. Albrecht, J. S. Babischkin, Y. Lidor, L. D. Anderson, L. C. Udoff, and G. J. Pepe Effect of estrogen on angiogenesis in co-cultures of human endometrial cells and microvascular endothelial cells Hum. Reprod., October 1, 2003; 18(10): 2039 - 2047. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Vonnahme, B. W. Hess, T. R. Hansen, R. J. McCormick, D. C. Rule, G. E. Moss, W. J. Murdoch, M. J. Nijland, D. C. Skinner, P. W. Nathanielsz, et al. Maternal Undernutrition from Early- to Mid-Gestation Leads to Growth Retardation, Cardiac Ventricular Hypertrophy, and Increased Liver Weight in the Fetal Sheep Biol Reprod, July 1, 2003; 69(1): 133 - 140. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. D. Albrecht, G. W. Aberdeen, A. L. Niklaus, J. S. Babischkin, D. L. Suresch, and G. J. Pepe Acute Temporal Regulation of Vascular Endothelial Growth/Permeability Factor Expression and Endothelial Morphology in the Baboon Endometrium by Ovarian Steroids J. Clin. Endocrinol. Metab., June 1, 2003; 88(6): 2844 - 2852. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Niklaus, G. W. Aberdeen, J. S. Babischkin, G. J. Pepe, and E. D. Albrecht Effect of Estrogen on Vascular Endothelial Growth/Permeability Factor Expression by Glandular Epithelial and Stromal Cells in the Baboon Endometrium Biol Reprod, June 1, 2003; 68(6): 1997 - 2004. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Niklaus, J. S. Babischkin, G. W. Aberdeen, G. J. Pepe, and E. D. Albrecht Expression of Vascular Endothelial Growth/Permeability Factor by Endometrial Glandular Epithelial and Stromal Cells in Baboons during the Menstrual Cycle and after Ovariectomy Endocrinology, October 1, 2002; 143(10): 4007 - 4017. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. A. Hildebrandt, J. S. Babischkin, R. D. Koos, G. J. Pepe, and E. D. Albrecht Developmental Regulation of Vascular Endothelial Growth/Permeability Factor Messenger Ribonucleic Acid Levels in and Vascularization of the Villous Placenta During Baboon Pregnancy Endocrinology, May 1, 2001; 142(5): 2050 - 2057. [Abstract] [Full Text]
|
|
|
|
 |
|
 X. Long, K. A. Burke, R. M. Bigsby, and K. P. Nephew Effects of the Xenoestrogen Bisphenol A on Expression of Vascular Endothelial Growth Factor (VEGF) in the Rat Experimental Biology and Medicine, May 1, 2001; 226(5): 477 - 482. [Abstract] [Full Text]
|
|
|
|
|
|
L. P. Reynolds and D. A. Redmer Angiogenesis in the Placenta Biol Reprod, April 1, 2001; 64(4): 1033 - 1040. [Abstract] [Full Text]
|
|
|
|
 |
|
 S. M. Hyder and G. M. Stancel Regulation of Angiogenic Growth Factors in the Female Reproductive Tract by Estrogens and Progestins Mol. Endocrinol., June 1, 1999; 13(6): 806 - 811. [Full Text]
|
|
|
|
|
|
L. P. Reynolds, J. D. Kirsch, K. C. Kraft, D. L. Knutson, W. J. McClaflin, and D. A. Redmer Time-Course of the Uterine Response to Estradiol-17ß in Ovariectomized Ewes: Uterine Growth and Microvascular Development Biol Reprod, July 1, 1998; 59(3): 606 - 612. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
