| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
a Department of Cell Biology, Vanderbilt University, Nashville, Tennessee 37232
b Reproductive Sciences, Oregon Regional Primate Research Center, Beaverton, Oregon 97006
Matrix metalloproteinases (MMPs) are highly expressed in the human endometrium during menstruation, and these enzymes participate in the cyclic destruction and regeneration characteristic of the primate endometrium. To examine hormonal regulation of MMPs in vivo, we evaluated MMP expression and localization in the endometrium of ovariectomized rhesus macaques under various hormonal conditions. Although all MMPs were up-regulated by progesterone (P4) withdrawal, their expression declined spontaneously after menstruation in the absence of P4. Of 7 MMPs examined, only matrilysin and stromelysin-3 were suppressed any further when P4 levels were experimentally re-elevated. MMP expression was confined to the upper functionalis zone during menstruation, but after menstrual breakdown was complete, matrilysin and the tissue inhibitor of MMPs, TIMP-1, shifted expression from the functionalis to the basalis zone in the absence of both estradiol and P4. The spiral arteries in the functionalis, but not the basalis, were intense foci of MMP and TIMP-1 expression. Menstruation and MMP expression after P4 withdrawal were similar in both the presence and absence of estradiol. In sum, endometrial MMPs in vivo are strongly up-regulated by P4 withdrawal, but zone-specific tissue gradients greatly influence the pattern and degree of MMP expression.
2 Correspondence: Robert M. Brenner, Reproductive Sciences, Oregon Regional Primate Research Center, 505 N.W. 185th Avenue, Beaverton, OR 97006. FAX: 503 690 5563; rmbrenner{at}compuserve.com
This article has been cited by other articles:
|
|
 |
|
  E. van Esch, J. M. Cline, E. Buse, and G. F. Weinbauer The Macaque Endometrium, with Special Reference to the Cynomolgus Monkey (Macaca fascicularis) Toxicol Pathol, December 1, 2008; 36(7_suppl): 67S - 100S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Cao, K. Mah, R.S. Carroll, O.D. Slayden, and R.M. Brenner Progesterone withdrawal up-regulates fibronectin and integrins during menstruation and repair in the rhesus macaque endometrium Hum. Reprod., December 1, 2007; 22(12): 3223 - 3231. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G B Godbole, D N Modi, and C P Puri Regulation of homeobox A10 expression in the primate endometrium by progesterone and embryonic stimuli Reproduction, September 1, 2007; 134(3): 513 - 523. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. R. A. Sherwin, A. M. Sharkey, P. Cameo, P. M. Mavrogianis, R. D. Catalano, S. Edassery, and A. T. Fazleabas Identification of Novel Genes Regulated by Chorionic Gonadotropin in Baboon Endometrium during the Window of Implantation Endocrinology, February 1, 2007; 148(2): 618 - 626. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. I. Gorodeski Estrogen Decrease in Tight Junctional Resistance Involves Matrix-Metalloproteinase-7-Mediated Remodeling of Occludin Endocrinology, January 1, 2007; 148(1): 218 - 231. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Collette, R. Maheux, J. Mailloux, and A. Akoum Increased expression of matrix metalloproteinase-9 in the eutopic endometrial tissue of women with endometriosis Hum. Reprod., December 1, 2006; 21(12): 3059 - 3067. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Vassilev, C. M. Pretto, P. B. Cornet, D. Delvaux, Y. Eeckhout, P. J. Courtoy, E. Marbaix, and P. Henriet Response of Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases Messenger Ribonucleic Acids to Ovarian Steroids in Human Endometrial Explants Mimics Their Gene- and Phase-Specific Differential Control in Vivo J. Clin. Endocrinol. Metab., October 1, 2005; 90(10): 5848 - 5857. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Germeyer, A. E. Hamilton, L. S. Laughlin, B. L. Lasley, R. M. Brenner, L. C. Giudice, and N. R. Nayak Cellular Expression and Hormonal Regulation of Neuropilin-1 and -2 Messenger Ribonucleic Acid in the Human and Rhesus Macaque Endometrium J. Clin. Endocrinol. Metab., March 1, 2005; 90(3): 1783 - 1790. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Collette, C. Bellehumeur, R. Kats, R. Maheux, J. Mailloux, M. Villeneuve, and A. Akoum Evidence for an increased release of proteolytic activity by the eutopic endometrial tissue in women with endometriosis and for involvement of matrix metalloproteinase-9 Hum. Reprod., June 1, 2004; 19(6): 1257 - 1264. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. B. Nothnick, X. Zhang, and H.-E Zhou Steroidal Regulation of Uterine Edema and Tissue Inhibitors of Metalloproteinase (TIMP)-3 Messenger RNA Expression Is Altered in TIMP-1-Deficient Mice Biol Reprod, February 1, 2004; 70(2): 500 - 508. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Goffin, C. Munaut, F. Frankenne, S. Perrier d'Hauterive, A. Beliard, V. Fridman, P. Nervo, A. Colige, and J.-M. Foidart Expression Pattern of Metalloproteinases and Tissue Inhibitors of Matrix-Metalloproteinases in Cycling Human Endometrium Biol Reprod, September 1, 2003; 69(3): 976 - 984. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. E. Curry Jr. and K. G. Osteen The Matrix Metalloproteinase System: Changes, Regulation, and Impact throughout the Ovarian and Uterine Reproductive Cycle Endocr. Rev., August 1, 2003; 24(4): 428 - 465. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. Brenner, O. D. Slayden, W. H. Rodgers, H. O.D. Critchley, R. Carroll, X. J. Nie, and K. Mah Immunocytochemical assessment of mitotic activity with an antibody to phosphorylated histone H3 in the macaque and human endometrium Hum. Reprod., June 1, 2003; 18(6): 1185 - 1193. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q.-L. Li, S. A. Illman, H.-M. Wang, D.-L. Liu, J. Lohi, and C. Zhu Matrix metalloproteinase-28 transcript and protein are expressed in rhesus monkey placenta during early pregnancy Mol. Hum. Reprod., April 1, 2003; 9(4): 205 - 211. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. B. Cornet, C. Picquet, P. Lemoine, K. G. Osteen, K. L. Bruner-Tran, S. Tabibzadeh, P. J. Courtoy, Y. Eeckhout, E. Marbaix, and P. Henriet Regulation and Function of LEFTY-A/EBAF in the Human Endometrium. mRNA EXPRESSION DURING THE MENSTRUAL CYCLE, CONTROL BY PROGESTERONE, AND EFFECT ON MATRIX METALLOPROTEINASES J. Biol. Chem., November 1, 2002; 277(45): 42496 - 42504. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Li, H. Wang, Y. Zhao, H. Lin, Q. A. Sang, and C. Zhu Identification and specific expression of matrix metalloproteinase-26 in rhesus monkey endometrium during early pregnancy Mol. Hum. Reprod., October 1, 2002; 8(10): 934 - 940. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Leyendecker, M. Herbertz, G. Kunz, and G. Mall Endometriosis results from the dislocation of basal endometrium Hum. Reprod., October 1, 2002; 17(10): 2725 - 2736. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Song, T. Rutherford, F. Naftolin, S. Brown, and G. Mor Hormonal regulation of apoptosis and the Fas and Fas ligand system in human endometrial cells Mol. Hum. Reprod., May 1, 2002; 8(5): 447 - 455. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. R. Nayak and R. M. Brenner Vascular Proliferation and Vascular Endothelial Growth Factor Expression in the Rhesus Macaque Endometrium J. Clin. Endocrinol. Metab., April 1, 2002; 87(4): 1845 - 1855. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. B. Nothnick Disruption of the Tissue Inhibitor of Metalloproteinase-1 Gene in Reproductive-Age Female Mice Is Associated with Estrous Cycle Stage-Specific Increases in Stromelysin Messenger RNA Expression and Activity Biol Reprod, December 1, 2001; 65(6): 1780 - 1788. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Wang, Q. Li, L. Shao, and C. Zhu Expression of Matrix Metalloproteinase-2, -9, -14, and Tissue Inhibitors of Metalloproteinase-1, -2, -3 in the Endometrium and Placenta of Rhesus Monkey (Macaca mulatta) During Early Pregnancy Biol Reprod, July 1, 2001; 65(1): 31 - 40. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. E. Curry Jr and K. G. Osteen Cyclic Changes in the Matrix Metalloproteinase System in the Ovary and Uterus Biol Reprod, May 1, 2001; 64(5): 1285 - 1296. [Abstract] [Full Text]
|
|
|
|
|
|
H. O. D. Critchley, R. M. Brenner, T. A. Henderson, K. Williams, N. R. Nayak, O. D. Slayden, M. R. Millar, and P. T. K. Saunders Estrogen Receptor {beta}, But Not Estrogen Receptor {{alpha}}, Is Present in the Vascular Endothelium of the Human and Nonhuman Primate Endometrium J. Clin. Endocrinol. Metab., March 1, 2001; 86(3): 1370 - 1378. [Abstract] [Full Text]
|
|
|
|
|
|
N. R. Nayak, H. O. D. Critchley, O. D. Slayden, A. Menrad, K. Chwalisz, D. T. Baird, and R. M. Brenner Progesterone Withdrawal Up-Regulates Vascular Endothelial Growth Factor Receptor Type 2 in the Superficial Zone Stroma of the Human and Macaque Endometrium: Potential Relevance to Menstruation J. Clin. Endocrinol. Metab., September 1, 2000; 85(9): 3442 - 3452. [Abstract] [Full Text]
|
|
|
|
 |
|
 K. E. Cox, K. L. Sharpe-Timms, N. Kamiya, M. Saraf, K. M. Donnelly, and A. T. Fazleabas Differential Regulation of Stromelysin-1 (Matrix Metalloproteinase-3) and Matrilysin (Matrix Metalloproteinase-7) in Baboon Endometrium Reproductive Sciences, July 1, 2000; 7(4): 242 - 248. [Abstract] [PDF]
|
|
|
|
|
|
O. D. Slayden, J. S. Rubin, D. L. Lacey, and R. M. Brenner Effects of Keratinocyte Growth Factor in the Endometrium of Rhesus Macaques during the Luteal-Follicular Transition J. Clin. Endocrinol. Metab., January 1, 2000; 85(1): 275 - 285. [Abstract] [Full Text]
|
|
|
|
|
|
K. Liu, J. I. Olofsson, P. Wahlberg, and T. Ny Distinct Expression of Gelatinase A [Matrix Metalloproteinase (MMP)-2], Collagenase-3 (MMP-13), Membrane Type MMP 1 (MMP-14), and Tissue Inhibitor of MMPs Type 1 Mediated by Physiological Signals During Formation and Regression of the Rat Corpus Luteum Endocrinology, November 1, 1999; 140(11): 5330 - 5338. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
