| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
a Department of Physiology and Endocrinology and
b Department of Surgery, Urology Section, Medical College of Georgia, Augusta, Georgia 30912-3000
Ongoing studies in this laboratory are designed to determine the role of androgens in the maintenance of the erectile response in the rat. Testosterone-treated castrated rats (TESTO) and untreated castrated rats (CASTRATE) were used for measurement of the rate at which blood flows into the cavernous sinuses by timed collections of blood after partial amputation of the penis. A laser Doppler flow meter was employed to determine whether androgens also regulate the veno-occlusive mechanism that controls the rate of blood flow out of the sinuses. Erection was induced by direct electrical stimulation of the autonomic ganglion that controls cavernosal blood flow in the erectile response. The results of these studies showed that blood flow into the sinuses was approximately twice as great in the TESTO animals as the CASTRATE rats. Furthermore, during ganglionic stimulation, veno-occlusion occurred in the TESTO rats but failed to occur in the CASTRATE rats. The dependence of these responses on nitric oxide (NO) was demonstrated by showing that injection of sodium nitroprusside (SNP) enhances the intracavernosal pressure response in TESTO rats but not CASTRATE animals. However, when SNP injection was combined with ganglionic stimulation, veno-occlusion did occur in the CASTRATE animals. Taken together, these studies show that both the rate of blood flow into the cavernous sinuses and the blood flow out are under androgenic regulation and may involve the actions of NO.
This article has been cited by other articles:
|
|
 |
|
  A. A. Yassin and F. Saad Testosterone and Erectile Dysfunction J Androl, November 1, 2008; 29(6): 593 - 604. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. C. da Costa Goncalves, R. Leite, R. A. Fraga-Silva, S. V. Pinheiro, A. B. Reis, F. M. Reis, R. M. Touyz, R. C. Webb, N. Alenina, M. Bader, et al. Evidence that the vasodilator angiotensin-(1 7)-Mas axis plays an important role in erectile function Am J Physiol Heart Circ Physiol, October 1, 2007; 293(4): H2588 - H2596. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Traish, P. Toselli, S.-J. Jeong, and N. N. Kim Adipocyte Accumulation in Penile Corpus Cavernosum of the Orchiectomized Rabbit: A Potential Mechanism for Veno-occlusive Dysfunction in Androgen Deficiency J Androl, March 1, 2005; 26(2): 242 - 248. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. J. Selvage, S. Y. Lee, L. H. Parsons, D. O. Seo, and C. L. Rivier A Hypothalamic-Testicular Neural Pathway Is Influenced by Brain Catecholamines, But Not Testicular Blood Flow Endocrinology, April 1, 2004; 145(4): 1750 - 1759. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Musicki, M. A. Palese, J. K. Crone, and A. L. Burnett Phosphorylated Endothelial Nitric Oxide Synthase Mediates Vascular Endothelial Growth Factor-Induced Penile Erection Biol Reprod, February 1, 2004; 70(2): 282 - 289. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Palese, J. K. Crone, and A. L. Burnett A Castrated Mouse Model of Erectile Dysfunction J Androl, September 1, 2003; 24(5): 699 - 703. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Traish, R. Munarriz, L. O'Connell, S. Choi, S. W. Kim, N. N. Kim, Y.-H. Huang, and I. Goldstein Effects of Medical or Surgical Castration on Erectile Function in an Animal Model J Androl, May 1, 2003; 24(3): 381 - 387. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K.-E. Andersson Pharmacology of Penile Erection Pharmacol. Rev., September 1, 2001; 53(3): 417 - 450. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. M. Mills, D. M. Pollock, R. W. Lewis, H. S. Branam, and C. J. Wingard Endothelin-1-induced vasoconstriction is inhibited during erection in rats Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2001; 281(2): R476 - R483. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
