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Biology of Reproduction, Vol 6, 109-116, Copyright © 1972 by Society for the Study of Reproduction
1 Department of Obstetrics-Gynecology, Biochemistry and the Endocrine Laboratory,
University of Miami School of Medicine, Miami, Florida The injection of cyclic AMP directly into the Graafian follicles of estrous rabbits inhibited the luteinization induced by luteinizing hormone. This inhibition was found to be
specific. Furthermore, destruction of endogenous cyclic AMP by intrafollicular injection of
phosphodiesterase produced luteinization. These results suggest that the process of luteinization might normally be held in check by cyclic AMP.
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