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Biology of Reproduction, Vol 6, 51-57, Copyright © 1972 by Society for the Study of Reproduction

Rabbit Antiserum to Rat Deciduoma

K. YOSHINAGA 1

1 Laboratory of Human Reproduction and Reproductive Biology and Department of Anatomy, Harvard Medical School, Boston, Massachusetts 02115


Antiserum to rat deciduoma was produced in the rabbit. The antiserum had an inhibitory effect on deciduoma formation when injected into the uterine lumen of pseudopregnant rats immediately after traumatization of the uterus. Normal rabbit serum had no inhibitory effect. The antiserum after absorption with the extract of immature rat uterus indicated the presence of a component specifically reactive to the deciduoma extract by an agar gel double diffusion test. This was shown by a precipitin line between deciduoma extract and the antiserum from which nonspecific antibodies to rat uterine components had been removed. The antiserum after absorption with the extract of immature rat uterus inhibited deciduoma formation when given locally into the uterine lumen.

Submitted on February 5, 1971




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Copyright © 1972 by the Society for the Study of Reproduction.