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Biology of Reproduction, Vol 6, 58-66, Copyright © 1972 by Society for the Study of Reproduction

The Effect of Human Chorionic Gonadotrophin and Luteinizing Hormone Upon the Membrane Potential of Unovulated Frog Oocytes

JOHN E. DAWSON 1, and JOHN T. CONRAD 2

1 Senior Fellow, Department of Obstetrics and Gynecology, School of Medicine, University of Washington, Seattle, Washington.
2 Department of Physiology and Biophysics, Obsterics and Gynecology, School of Medicine, University of Washington, Seattle, WA 98105.


The negative membrane potentials of isolated ovarian oocytes in normal Ringer’s solution have been studied by microelectrodes. These potentials may be modified by the application of luteinizing hormone (LH) and Human Chorionic Gonadotrophin (HCG) to the bath surrounding the eggs. The majority of oocytes responded to these hormones by depolarization of the negative potential. Hyperpolarizing and biphasic responses were also noted. The threshold dose for a bioelectrical response was about 25 IU per ml for LH and 45 IU per ml for HCG.

It is suggested that the change in membrane potentials noted here are due to luteinizing hormones. This effect of LH or HCG may be the result of a direct effect upon the oocyte or it may be an indirect response mediated via a substance released from closely adhering follicular cells.

 Submitted on March 8, 1971




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Electrical events during gamete maturation and fertilization in animals and humans
Hum. Reprod. Update, January 1, 2004; 10(1): 53 - 65.
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Copyright © 1972 by the Society for the Study of Reproduction.