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Biology of Reproduction 60, 227-233 (1999)
©Copyright 1999 Society for the Study of Reproduction, Inc.

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From the Decidual Cell Internet: Trophoblast-Recognizing T Cells

Petra Arck1,a, Johannes Dietlb, and David Clarkc

a Charité, Campus Virchow Klinikum, Humbolt University, 13353 Berlin, Germany b Department of Obstetrics and Gynecology, University of Würzberg, 97080 Würzberg, Germany c Departments of Medicine and Obstetrics/Gynocology, McMaster University, Hamilton, Ontario, Canada L7N 3Z5

The mammalian fetus has been perceived, paradoxically, as a successful allograft, a successful tumor, and a successful parasite. Success depends on fetal trophoblast cells, which form the interface with the mother. The maternal immune system is involved in the success of pregnancy and in its failure. The discovery that maternal {gamma}{delta} T cells may recognize and react to the fetal trophoblast and the definition of a vascular mechanism whereby their Th1 and Th2/3-type cytokines may abort embryos replaces confusion and debate with a new and simple clarity that enables further research.

1 Correspondence and current address: Petra Arck, Charité, Campus Virchow Klinikum, Med. Klinik/Psychosomatik, Augustenburger Platz 1, 13353 Berlin, Germany. FAX: +49 30 450 53900; petra.arck{at}charite.de




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Copyright © 1999 by the Society for the Study of Reproduction.