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a Department of Veterinary Biosciences, University of Illinois, Urbana, Illinois 61802
b Department of Cell Biology, Neurobiology, and Anatomy, Loyola University-Chicago, Maywood, Illinois 60153
As a first step in determining possible influences of the newly discovered estrogen receptor (ER)-ß on reproduction, we have localized mRNA for ER-ß within the male sheep hypothalamus using in situ hybridization and a rat ER-ß cRNA probe. Highest amounts of hybridization signal were observed in the preoptic area (POA), bed nucleus of the stria terminalis, paraventricular nucleus, and supraoptic nucleus. Relatively moderate amounts of hybridization signal were observed in the retrochiasmatic area (RCH), anterior hypothalamic area, dorsomedial hypothalamus, and lateral hypothalamus. Only a low level of hybridization signal was observed in the ventromedial hypothalamus, suprachiasmatic nucleus, and arcuate nucleus. The presence of ER-ß mRNA in several areas of the male sheep hypothalamus suggests multiple functions for this receptor. The distribution of ER-ß in the ovine hypothalamus was similar to that described for the rat, suggesting a high degree of functional conservation across species. A role for ER-ß in influencing reproduction is suggested by its presence in the POA and RCH, regions of the hypothalamus that control reproduction.
2 Correspondence and current address: Stan Hileman, 325 Research North, Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Ave., Boston, MA 02215. FAX: 617 667 2927; shileman{at}caregroup.harvard.edu
3 Current address: Robert J. Handa, Department of Anatomy and Neurobiology, Colorado State University, Fort Collins, CO 80523.
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