HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal My Folders Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Schnell, S. A. Articles by El Halawani, M. E. Search for Related Content PubMed PubMed Citation Articles by Schnell, S. A. Articles by El Halawani, M. E. Agricola Articles by Schnell, S. A. Articles by El Halawani, M. E.

D1 and D2 Dopamine Receptor Messenger Ribonucleic Acid in Brain and Pituitary during the Reproductive Cycle of the Turkey Hen¹

^a Department of Animal Science, University of Minnesota, St. Paul, Minnesota 55109

The regulation of prolactin secretion during the reproductive cycle of seasonal breeding birds appears to be largely under the stimulatory influence of hypothalamic vasoactive intestinal peptide (VIP). However, the factors influencing VIP secretion, and hence prolactin release, in birds remain largely unexplored. Recent evidence has demonstrated that dopamine and dopamine receptors may affect VIP and prolactin release in birds. The differential expression of dopamine receptors on hypothalamic VIP-releasing neurons may affect the degree of prolactinemia observed during the reproductive cycle of birds. In order to examine this hypothesis, we used reverse transcription-polymerase chain reaction to quantitate the levels of D1 and D2 dopamine receptor subtype mRNAs in the brain of the domestic turkey hen during the reproductive cycle. No significant difference in hypothalamic expression of D1 or D2 dopamine receptor subtypes during the reproductive cycle was observed. However, pronounced differences in D1_D and D2 mRNAs were detected in cortex and cerebellum. Interestingly, there was a dramatic increase in pituitary D1_D receptor mRNA during the reproductive stages of laying and incubation of eggs, which paralleled the hyperprolactinemic state of the turkey reproductive cycle. In addition, pituitary D2 receptor mRNA steadily increased throughout the reproductive cycle. In light of these observations, a modified hypothesis regarding the effects of dopamine on prolactin secretion is discussed.

¹ These studies were supported by grant number 97-35203-4960 from the United States Department of Agriculture.

² Correspondence: Steve Schnell, 4-144 Jackson Hall, Dept. Cell Biology and Neuroanatomy, 321 Church Street S.E., University of Minnesota, Minneapolis, MN 55455. FAX: 612 624 8118; schnell{at}lenti.med.umn.edu

This article has been cited by other articles:

				T. Sato, M. M. Meguid, S. O. Fetissov, C. Chen, and L. Zhang Hypothalamic dopaminergic receptor expressions in anorexia of tumor-bearing rats Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2001; 281(6): R1907 - R1916. [Abstract] [Full Text] [PDF]