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Biology of Reproduction 61, 411-415 (1999)
©Copyright 1999 Society for the Study of Reproduction, Inc.

Articles

Pulsatile Output of Prostaglandin F2{alpha} Does Not Increase Around the Time of Luteolysis in the Pregnant Goat1

M.M. Forda, G.D. Thorburn3,a, D.J. Caddya, and I.R. Young2,a

a Department of Physiology, Monash University, Clayton, Victoria 3168, Australia

Prostaglandin (PG) F2{alpha} secreted from the uterus is the luteolysin of the estrous cycle and is also believed to be responsible for luteolysis in the pregnant doe at term. We have reported that basal progesterone concentrations decrease before basal PGF2{alpha} concentrations increase, which is inconsistent with this view. In this study we investigated whether luteolysis is associated with increased frequency or amplitude of pulsatile PGF2{alpha} secretion in does over the last 2 wk of gestation.

Progesterone concentrations decreased approximately 1 wk before parturition. There was no accompanying increase in PGF2{alpha} concentrations or pulse frequency, and those pulses that were observed were of lesser amplitude and duration than those that have been associated with luteolysis in cycling ewes. A small increase in PGF2{alpha} pulse frequency was identified during the 3 days before parturition, but this was not associated with any change in progesterone concentrations. The biological significance of these small changes in PGF2{alpha} pulse frequency is obscure, although the high concentration of this eicosanoid at labor may have been related to the final, precipitous decline in plasma progesterone concentrations. These findings do not support the notion that PGF2{alpha} is the principal luteolysin in the pregnant doe at term.

1 This study was funded by a grant from the Australian Research Council to I.R.Y. and G.D.T.

2 Correspondence: I.R. Young, Dept. of Physiology, Monash University, Wellington Rd., Clayton, Victoria, Australia 3168. FAX: 03 9905 2547; ross.young{at}med.monash.edu.au

3 Deceased 28 October 1996.






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Copyright © 1999 by the Society for the Study of Reproduction.