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a Department of Anatomy and Reproductive Biology, University of Hawaii Medical School, Honolulu, Hawaii 96822
b Department of Biological Sciences, Asahikawa Medical College, Asahikawa, Japan 078-8510
To assess the relationship between mouse sperm head morphology and karyotype, sperm heads with either a normal or an abnormal morphology were injected individually into enucleated mouse oocytes that were karyotyped at the metaphase of the first cleavage. BALB/c male mice that produce an unusually high proportion of morphologically abnormal spermatozoa were used as sperm donors. Abnormal karyotypes were found in a significantly higher proportion of eggs injected with severely misshapen sperm heads (36–38%) as compared to those injected with normal and quasi-normal heads (15–21%) (p < 0.01). Most karyotype abnormalities were structural rather than numerical, the most common being breaks and exchanges of chromosome type in both normal and abnormal spermatozoa.
2 Correspondence: H. Kishikawa, Department of Anatomy and Reproductive Biology, University of Hawaii Medical School, 1960 East-West Road, Honolulu, HI 96822. FAX: 808 956 5474; kishi{at}uro.med.osaka-u.ac.jp
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