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a Section of Neurobiology, Physiology and Behavior, University of California at Davis, Davis, California 95616
The nature of genetic differences in ovarian responsiveness to gonadotropins was examined in mouse strains and subspecies. Hormone-induced ovulation rate (HIOR) differed 5-fold between Mus musculus strains A/J (10.3 ± 1.6 eggs in cumulus) and C57BL/6J (B6) (47.3 ± 2.5 eggs in cumulus), and 6-fold among Mus spretus lines and crosses. Subspecies differed up to 10-fold in HIOR (Mus spretus/Ros: 4.8 ± 1.0 eggs in cumulus versus B6). An additional experiment examined the genetics of HIOR in crosses. The number of eggs ovulated in response to equine chorionic gonadotropin (CG)/human CG averaged 8.4 ± 0.9 in A/J, 40.7 ± 1.7 in B6, 33.9 ± 1.6 in B6AF1, and 20.2 ± 0.3 in (B6xA)xA backcrosses. The 5-fold genetic differences in hormone-induced ovulation rate between Mus musculus strains A/J and B6 segregated in backcrosses as though they were controlled by the action of approximately 3 loci with major effects. This study demonstrates genetic variation in HIOR both within and between mouse subspecies, and provides confirmation that genetic differences are a major source of variation in the regulation of ovarian responsiveness to gonadotropins.
2 Correspondence: Jimmy Spearow, Section of NPB, Rm 196 Briggs Hall, University of California at Davis, One Shields Ave., Davis, CA 95616. FAX: 530 752 5582; jlspearow{at}ucdavis.edu
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