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a Department of Pathobiology, College of Veterinary Medicine, University of Missouri, Columbia, Missouri 65211
Although previous studies have shown that members of the transforming growth factor ß (TGFß) family are expressed in the seminiferous tubules, the functions of these growth factors in spermatogenesis remain elusive. In order to shed light on the mechanisms of TGFß action in spermatogenesis, it is crucial to determine whether and where their downstream signaling molecules are expressed in the testis. We examined the expression of Smad2, an intracellular signal transducer of the TGFßs, in mouse testes by in situ hybridization and immunohistochemistry. Both Smad2 mRNA and protein were detected in meiotic germ cells, from preleptotene to pachytene spermatocytes, but not in postmeiotic germ cells. Smad2 expression was also observed in interstitial cells and Sertoli cells. Therefore, our data provide molecular evidence for TGFß signal transduction during spermatogenesis.
2 Correspondence. FAX: 573 884 5414; zhaog{at}missouri.edu
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