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Biology of Reproduction 61, 1409-1418 (1999)
©Copyright 1999 Society for the Study of Reproduction, Inc.

Articles

Effects of Recombinant Ovine Interferon Tau, Placental Lactogen, and Growth Hormone on the Ovine Uterus1

Thomas E. Spencera, Allison Graya, Greg A. Johnsona, Kristin M. Taylora, Arieh Gertlerb, Elisha Gootwinec, Troy L. Ott3,a, and Fuller W. Bazer2,a

a Center for Animal Biotechnology and Genomics, Albert B. Alkek Institute of Biosciences and Technology, Texas A&M University System Health Science Center, and Department of Animal Science, Texas A&M University,College Station, Texas 77843-2471 b Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, Rehovot 76100, Israel c Institute of Animal Science, Agricultural Research Organization, Volcani Center, Bet Dagan 50650, Israel

Studies were conducted to determine effects of intrauterine administration of recombinant ovine interferon {tau} (IFN{tau}), placental lactogen (PL), and growth hormone (GH) on endometrial function. In the first study, administration of IFN{tau} to cyclic ewes for one period (Days 11–15) resulted in an interestrous interval (IEI) of ~30 days, whereas administration for two periods (Days 11–15 and Days 21–25) extended the IEI to greater than 50 days. Administration of IFN{tau} from Days 11 to 15 and of PL or GH from Days 21 to 25 failed to extend the IEI more than for IFN{tau} alone. In the second study, effects of IFN{tau}, PL, and GH on endometrial differentiation and function were determined in ovariectomized ewes receiving ovarian steroid replacement therapy. Endometrial expression of mRNAs for estrogen receptor (ER), progesterone receptor (PR), and oxytocin receptor (OTR) were not affected by PL or GH treatment; however, uterine milk protein mRNA levels and stratum spongiosum gland density were increased by both PL and GH treatments. Collectively, results indicated that 1) PL and GH do not regulate endometrial PR, ER, and OTR expression or affect corpus luteum life span; 2) down-regulation of epithelial PR expression is requisite for progesterone induction of secretory gene expression in uterine glandular epithelium; 3) effects of PL and GH on endometrial function require IFN{tau}; and 4) PL and GH regulate endometrial gland proliferation and perhaps differentiated function.

1 This work was supported by BARD Grant US-2643–95.

2 Correspondence: Fuller W. Bazer, Department of Animal Science and Center for Animal Biotechnology and Genomics, Albert B. Alkek Institute of Biosciences and Technology, 442D Kleberg Center, Texas A&M University, College Station, TX 77843-2471. FAX: 409 862 2662; fbazer{at}cvm.tamu.edu

3 Current address: Animal and Veterinary Science Department, 216 Agricultural Sciences Building, University of Idaho, Moscow, ID 83844-2330.




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Copyright © 1999 by the Society for the Study of Reproduction.