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Increased Intracortical Bone Remodeling During Lactation in Beagle Dogs¹

^a Radiobiology Division, School of Medicine, University of Utah, Salt Lake City, Utah 84108-1218 ^b Department of Veterans Affairs Medical Center, Salt Lake City, Utah 84108 ^c Novartis Pharma AG, Basel, Switzerland ^d Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87185

There are substantial changes in skeletal and mineral metabolism during pregnancy and lactation. The purpose of this study was to determine the changes in intracortical bone remodeling and turnover during lactation in beagle dogs. A femur and rib were obtained from dogs near the end of lactation or soon after weaning and compared with nonlactating controls. Rib cortical bone had much higher bone turnover rates than did femoral diaphyseal cortical bone. The number of single-labeled osteons and the number of resorption spaces were significantly greater during lactation in both the rib and the femur. Additionally, the mineral apposition rate, basic multicellular unit activation frequency, and bone turnover rates were greater in the femoral cortical bone from the lactating dogs than from the controls. These data demonstrate that during lactation, intracortical bone remodeling increases, and this may provide a mechanism for the skeleton to be responsive to the calcium requirements of the mother. In addition, these data may help explain the transient decreases in cortical bone mineral density that are reported to occur during human lactation.

¹ This work was supported by grants DE-07008 and AR44806 from the National Institutes of Health and by the Department of Veterans Affairs Office of Research and Development.

² Correspondence: Scott C. Miller, Division of Radiobiology, University of Utah, 729 Arapeen Dr., Salt Lake City, UT 84108-1218. FAX: 801 581 7008; scmiller{at}hsc.utah.edu

This article has been cited by other articles:

				E. G. Vajda, B. M. Bowman, and S. C. Miller Cancellous and Cortical Bone Mechanical Properties and Tissue Dynamics During Pregnancy, Lactation, and Postlactation in the Rat Biol Reprod, September 1, 2001; 65(3): 689 - 695. [Abstract] [Full Text] [PDF]