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a Developmental Endocrinology Section,
b Reproductive Toxicology Group, Laboratory of Toxicology, Environmental Toxicology Program and Receptor Biology Section, Laboratory of Reproductive and Developmental Toxicology, Environmental Diseases and Medicine Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709
By the use of ribonuclease protection assay (RPA) combined with immunohistochemical techniques, the expression of estrogen receptor (ER) 
and ERß was mapped in the developing gonads and reproductive tracts of male and female mice from fetal day 14 to postnatal day 26 (PND 26). This study was designed to determine the pattern of expression of both ER subtypes in specific tissue compartments during development. In ovaries, ER mRNA was detected at all ages examined; ERß mRNA was seen as early as PND 1, and its expression increased with age. Immunolocalization showed ERß in differentiating granulosa cells of the ovary, whereas ER was predominantly seen in interstitial cells. The remainder of the female reproductive tract showed ER mRNA at all ages examined with little or no significant levels of ERß, except on PND 1 when a low level of message appeared. In males, ER and ERß mRNA were detected in the fetal testis; however, ERß gradually increased until PND 5 and subsequently diminished to undetectable levels by PND 26. Immunolocalization showed ER in the interstitial compartment of the testis, whereas ERß was seen predominantly in developing spermatogonia. The remainder of the male reproductive tract showed varying amounts of both receptors by RPA and immunostaining throughout development. These studies provide information useful in studying the role of both ER subtypes in normal differentiation, and they provide indications of differential tissue expression during development.
1 Correspondence: Retha R. Newbold, Mail Drop E4-02, NIEHS, 111 Alexander Drive, South Campus, P.O. Box 12233, Research Triangle Park, NC 27709. FAX: 919 541 4634; newbold1{at}niehs.nih.gov
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