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Biology of Reproduction 62, 622-627 (2000)
© 2000 Society for the Study of Reproduction, Inc.

Articles

Interferon-Tau and Progesterone Regulate Ubiquitin Cross-Reactive Protein Expression in the Ovine Uterus1

Greg A. Johnsona,b, Thomas E. Spencera,b, Robert C. Burghardta,c, Margaret M. Joycea,b, and Fuller W. Bazer2,a,b

a Center for Animal Biotechnology, b Institute of Biosciences and Technology, Texas A&M University System Health Center, Departments of Animal Science and c Veterinary Anatomy & Public Health, Texas A&M University, College Station, Texas 77843-2471

Ubiquitin cross-reactive protein (UCRP) is a functional ubiquitin homolog synthesized by the ruminant endometrium in response to conceptus-derived interferon-tau (IFN{tau}). Progesterone is required for IFN{tau} to exert antiluteolytic actions on the endometrium. Therefore, this study was designed to determine whether progesterone is requisite for IFN{tau} induction of UCRP expression within the ovine uterus. Cyclic ewes were ovariectomized and fitted with intrauterine (i.u.) catheters on Day 5 and treated daily with steroids (i.m.) and protein (i.u.) as follows: 1) progesterone (P, Days 5–24) and control serum proteins (CX, Days 11–24); 2) P and ZK 137.316 (ZK; progesterone receptor antagonist, Days 11–24) and CX proteins; 3) P and recombinant ovine IFN{tau} (roIFN{tau}, Days 11–24); or 4) P and ZK and roIFN{tau}. All ewes were hysterectomized on Day 25. In P-treated ewes, roIFN{tau} increased endometrial UCRP mRNA and protein levels. However, administration of ZK to ewes ablated roIFN{tau} induction of UCRP. Recombinant ovine IFN{tau} induced expression of UCRP mRNA in progestinized endometrial luminal (LE) and glandular (GE) epithelium as well as in both stratum compactum and spongiosum layers of the stroma (ST). Progesterone receptor protein was located in endometrial ST, but not in LE and GE from these ewes. Results support the hypothesis that progesterone is required for IFN{tau} induction of type I IFN-responsive genes, such as UCRP, in the ruminant uterus.

First decision: 11 October 1999.

1 Research supported in part by USDA-NRICGP 95-37203-2185 to F.W.B. and R.C.B.

2 Correspondence: Fuller W. Bazer, Department of Animal Science and Center for Animal Biotechnology and Genomics, 442D Kleberg Center, Texas A&M University, College Station, TX 77843-2471. FAX: 409 862 2662; fbazer{at}cvm.tamu.edu




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