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Biology of Reproduction 63, 683-687 (2000)
© 2000 Society for the Study of Reproduction, Inc.

Regular article

IL-15 Expression at Human Endometrium and Decidua

Kotaro Kitaya1,,a, Jinsuke Yasudaa, Izumi Yagia, Yoshihiro Tadaa, Shinji Fushikib, and Hideo Honjoa

a Department of Obstetrics and Gynecology and b Dynamic Pathology Research Institute, Kyoto Prefectural University of Medicine, Kyoto, 602-8566, Japan

ABSTRACT

A large number of natural killer (NK) cells appear in human uterine mucosa during the secretory phase and first trimester pregnancy. We investigated the expression of interleukin (IL)-15, a possible stimulator for these NK cells, in human endometrium and first trimester decidua. Semiquantitative reverse transcriptase-polymerase chain reaction revealed that IL-15 mRNA expression was stronger during the secretory phase and first trimester pregnancy than during the proliferative phase. Immunohistochemistry revealed that immunoreactivity for anti-IL-15 was higher during the secretory phase than it was during the proliferative phase. This was prominent in the perivascular stromal cells around invading spiral arteries during the mid- to late-secretory phase. In first trimester decidua, endothelial cells were also stained as strongly as stromal cells. A membrane-bound IL-15 molecule was detected on the surface of first trimester decidual cells by flow cytometry. Progesterone stimulated the release of soluble IL-15 in the supernatant of cultured decidual cells. These results suggest that IL-15 expression in human uterine mucosa corresponds to the fluctuation of uterine NK cells and that its production is hormonally controlled, especially by progesterone.

FOOTNOTES

First decision: 27 January 2000.

1 Correspondence: Kotaro Kitaya, Department of Obstetrics and Gynecology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan. FAX: 81 75 212 1265; kitaya{at}pop01.odn.ne.jp




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