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Regular Article |
, and Steroid Hormones from Bovine Mature Follicles In Vivo1
a Departments of Theriogenology and
b Animal Science, and
c University Farm, Obihiro University of Agriculture and Veterinary Medicine, Obihiro 080-8555, Japan
d Institute of Physiology, Technical University of Munich, 80350 Freising-Weihenstephan, Germany
e Departamento de Fisiologia, Facultad de Ciencias Veterinarias Universidad Nacional de Asuncion, San Lorenzo, Paraguay
ABSTRACT
We previously proposed that an endothelin-angiotensin-atrial natriuretic peptide system may contribute to inducing ovulation of mature bovine follicles by modulating follicular secretion of steroids and prostaglandins (PGs). Thus, this study aimed to determine the real-time changes in the local release of angiotensin II (Ang II), endothelin (ET), atrial natriuretic peptide (ANP), PGF2
, and steroid hormones from bovine mature follicles during the periovulatory period in vivo. Seven cows were treated for superovulation using FSH and PGF2 injections. Two dialysis capillary membranes per follicle were surgically implanted into the theca layer of mature follicles and connected to a microdialysis system (MDS). Fractions of the perfusate were collected from Day -1 (Day 0 = LH surge) to Day 3. Five out of seven treated cows were normally ovulated, and the newly formed corpora lutea were observed at the end of the experiment. In these five ovulated cows, the release of estradiol, androstenedione, and progesterone in the theca layer increased (P < 0.05) synchronously with the LH surge. Acute increases in PGF2 and Ang II concentrations in the ovarian venous plasma (OVP) were observed at 24–48 h after the peak of the LH surge, when multiple ovulations were expected to occur. The follicular Ang II release was low during the pre-LH surge period and rose (P < 0.05) at the beginning of the increase in the LH surge. On the other hand, ET-1 release dropped (P < 0.05) when plasma LH started to increase. However, no clear changes in ANP concentration in the MDS perfusate and plasma were observed. The above local changes in Ang II, PGF2, as well as steroid hormones were not observed in cows (n = 2) that did not show an LH surge and ovulation. The present results demonstrate for the first time the local release of Ang II, ET-1, and ANP from the bovine mature follicle in real-time in vivo and show that Ang II and PGF2 concentrations in the OVP acutely increase around the time of ovulation. The overall results support the concept of a local functional ET-Ang-ANP system in the bovine mature follicle that may be involved in the ovulatory process.
1 This study was supported by Grants-in-Aid for Scientific Research (11660276 and 12556046) and the Japan-Germany joint research project of the Japan Society for the Promotion of Science (JSPS), the Novartis Foundation (Japan) for the Promotion of Science, and the German Research Foundation (Scha 254/14-1). T.J.A is a postdoctoral fellow supported by JSPS, S.K. and K.H. were supported by H. Wilhelm Schaumann Stiftung, and A.M. was supported by Alexander von Humboldt Stiftung.
2 Correspondence. FAX: 81 155 49 5462; akiomiya{at}obihiro.ac.jp
3 Current address: T.J. Acosta, Dept. of Animal Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro 080-8555, Japan.
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