HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Temple, J. L. Articles by Rissman, E. F. Search for Related Content PubMed PubMed Citation Articles by Temple, J. L. Articles by Rissman, E. F. Agricola Articles by Temple, J. L. Articles by Rissman, E. F.

Acute Re-Feeding Reverses Food Restriction-Induced Hypothalamic-Pituitary-Gonadal Axis Deficits¹

^a Neuroscience Graduate Program and Department of Biology, University of Virginia, Charlottesville, Virginia 22903

ABSTRACT

Undernutrition has well-established effects on female reproduction. Here we describe the effects of food restriction on aspects of the hypothalamic-pituitary-gonadal (HPG) axis in the female musk shrew. We determined that acute re-feeding reverses deficits brought on by food restriction. Two days of food restriction led to an increase in proGnRH immunoreactive cells in the preoptic area relative to ad libitum-fed controls (AL). This increase was reversed by 90 min of ad libitum feeding in the re-fed females (RF). In addition, food-restricted (FR) females had significantly greater GnRH content in the median eminence than either the AL or RF females. After GnRH was administered, the majority of females in all food conditions ovulated, yet the FR females had significantly fewer corpora lutea than either the AL or RF animals. These data show that food restriction impairs HPG axis function in female musk shrews, and that some of these impairments can be rapidly reversed by acute re-feeding.

FOOTNOTES

First decision: 2 June 2000.

¹ This work was supported by RO1 NS 35429 and KO2 MH 01349. J.L.T. was supported by an NSF predoctoral fellowship.

² Correspondence. FAX: 804 243 8433; rissman{at}virginia.edu

This article has been cited by other articles:

				J. S. Schneider and E. F. Rissman Gonadotropin-releasing hormone II: A multi-purpose neuropeptide Integr. Comp. Biol., April 19, 2008; (2008) icn018v1. [Abstract] [Full Text] [PDF]

				A. S. Kauffman, K. Bojkowska, A. Wills, and E. F. Rissman Gonadotropin-Releasing Hormone-II Messenger Ribonucleic Acid and Protein Content in the Mammalian Brain Are Modulated by Food Intake Endocrinology, November 1, 2006; 147(11): 5069 - 5077. [Abstract] [Full Text] [PDF]

				J. L. Temple, R. P. Millar, and E. F. Rissman An Evolutionarily Conserved Form of Gonadotropin-Releasing Hormone Coordinates Energy and Reproductive Behavior Endocrinology, January 1, 2003; 144(1): 13 - 19. [Abstract] [Full Text] [PDF]