Biol Reprod Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow My Folders
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Guttenbach, M.
Right arrow Articles by Schmid, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Guttenbach, M.
Right arrow Articles by Schmid, M.
Agricola
Right arrow Articles by Guttenbach, M.
Right arrow Articles by Schmid, M.
Biology of Reproduction 63, 1727-1729 (2000)
© 2000 Society for the Study of Reproduction, Inc.

Regular Article

Meiotic Nondisjunction of Chromosomes 1, 17, 18, X, and Y in Men More Than 80 Years of Age

M. Guttenbacha, F.-M. Köhnb, W. Engelc, and M. Schmid1,a

a Institut für Humangenetik, Universität Würzburg, Biozentrum, Am Hubland, 97074 Würzburg, Germany b Klinik und Poliklinik für Dermatologie und Allergologie, 80802 München, Germany c Institut für Humangenetik, Universität Göttingen, 37073 Göttingen, Germany

ABSTRACT

In order to evaluate a possible paternal age effect, testicular sperm cells from three men aged 81, 82, and 83 yr were analyzed by two-color- and three-color-fluorescence in situ hybridization for disomy rates of chromosomes 1, 17, 18, X, and Y as well as for diploidy frequencies. A minimum of 1500 sperm cells per donor and probe was evaluated due to the low number of spermatozoa in the preparations. Diploidy and disomy frequencies were in the same range as found in men aged <30 yr, a slight increase only being noticed for XY nuclei.

FOOTNOTES

First decision: 8 November 1999.

1 Correspondence: Michael Schmid, Department of Human Genetics, University of Würzburg, Biozentrum, Am Hubland, 97074 Würzburg, Germany. FAX: 49 931 8884069; m.schmid{at}biozentrum.uni-wuerzburg.de




This article has been cited by other articles:


Home page
 Hum ReprodHome page
S.S. Young, B. Eskenazi, F.M. Marchetti, G. Block, and A.J. Wyrobek
The association of folate, zinc and antioxidant intake with sperm aneuploidy in healthy non-smoking men
Hum. Reprod., May 1, 2008; 23(5): 1014 - 1022.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
B. Kuhnert and E. Nieschlag
Reproductive functions of the ageing male
Hum. Reprod. Update, July 1, 2004; 10(4): 327 - 339.
[Abstract] [Full Text] [PDF]

Home page
 J. Med. Genet.Home page
N Rives, G Langlois, A Bordes, N Simeon, and B Mace
Cytogenetic analysis of spermatozoa from males aged between 47 and 71 years
J. Med. Genet., October 1, 2002; 39(10): e63 - 63.
[Full Text] [PDF]

Home page
 Hum ReprodHome page
B. Eskenazi, A.J. Wyrobek, S.A. Kidd, X. Lowe, D. Moore II, K. Weisiger, and M. Aylstock
Sperm aneuploidy in fathers of children with paternally and maternally inherited Klinefelter syndrome
Hum. Reprod., March 1, 2002; 17(3): 576 - 583.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2000 by the Society for the Study of Reproduction.