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Biology of Reproduction 64, 784-789 (2001)
© 2001 Society for the Study of Reproduction, Inc.

Regular Article

Expression of Fas/Fas Ligand by Decidual Leukocytes in Hydatidiform Mole

Sutatip Wongweragiata,c, Roger F. Searleb, and Judith N. Bulmer1,c

a Departments of Microbiology and Immunology, b Obstetrics and Gynaecology, and c Pathology, University of Newcastle upon Tyne, Newcastle upon Tyne, NE1 4LP, United Kingdom

ABSTRACT

Complete hydatidiform moles are entirely paternally derived and, therefore, represent a complete intrauterine allograft that might be expected to provoke an altered maternal immune response compared with that of normal pregnancy. Uterine decidua contains a large leukocyte population, of which 10%–20% are T lymphocytes. Fas ligand (FasL) expression by placental trophoblast may induce apoptosis of Fas+ lymphocytes, thereby facilitating immune tolerance and survival of the molar trophoblast. Our previous studies have shown an increase in activated CD4+ decidual T cells in molar pregnancy compared with normal pregnancy. This study was designed to characterize and quantitate Fas/FasL expression by decidual leukocytes in complete and partial hydatidiform mole compared with that in normal early pregnancy using single and double immunohistochemical labeling (i.e., avidin-biotin-peroxidase and avidin-biotin-alkaline phosphatase). A significant increase was found in Fas and FasL expression by decidual CD4+ T cells in complete (Fas+, P = 0.0106; FasL+, P = 0.0081) and partial (Fas+, P = 0.0131; FasL+, P = 0.0051) hydatidiform moles, as was a significant decrease in Fas expression by decidual CD8+ T cells in complete (P = 0.0137) and partial (P = 0.0202) hydatidiform mole compared with normal early pregnancy. The implications of altered Fas/FasL status of decidual T-cell subsets in hydatidiform mole are also discussed.

FOOTNOTES

First decision: 3 August 2000.

1 Correspondence: J.N. Bulmer, Department of Pathology, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne, NE1 4LP, UK. FAX: 0191 222 8100; j.n.bulmer{at}ncl.ac.uk






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Copyright © 2001 by the Society for the Study of Reproduction.