HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal My Folders Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Curry, T. E. Articles by Osteen, K. G. Search for Related Content PubMed PubMed Citation Articles by Curry, T. E., Jr Articles by Osteen, K. G. Agricola Articles by Curry, T. E. Articles by Osteen, K. G.

Cyclic Changes in the Matrix Metalloproteinase System in the Ovary and Uterus¹

^a Department of Obstetrics and Gynecology, University of Kentucky, Lexington, Kentucky 40536-0293 ^b Women's Reproductive Health Research Center, Vanderbilt University, Nashville, Tennessee 37232-2519

With each estrous or menstrual cycle, extensive alterations occur in the extracellular matrix and connective tissue of the ovary and uterus. In the ovary, these changes occur during follicular development, breakdown of the follicular wall and extrusion of the oocyte, as well as during the formation and regression of the corpus luteum. In the uterus, the endometrium undergoes dramatic connective tissue turnover associated with tissue breakdown and subsequent regrowth during each menstrual cycle. These changes in the ovarian and uterine extracellular architecture are regulated, in part, by the matrix metalloproteinase (MMP) system. This system is comprised of both a proteolytic component, the MMPs, and associated inhibitors, and it is involved in connective tissue remodeling processes throughout the body. The current review highlights the key features of the MMP system and focuses on the changes in the MMPs and the tissue inhibitors of metalloproteinases during the dynamic remodeling that takes place in the ovary and uterus during the estrous and menstrual cycles.

First decision: 18 October 2000.

¹ Supported by grants to T.E.C. (NIH HD23195, HD34400, and the Lalor Foundation) and to K.G.O. through cooperative agreement U54 HD37321 as part of the Specialized Cooperative Centers Program in Reproductive Research and by the Endometriosis Association Research Program at Vanderbilt University.

² Correspondence: Thomas E. Curry, Jr., Department of Obstetrics and Gynecology, University of Kentucky Medical Center, 800 Rose Street, Room C355, Lexington, KY 40536-0293. FAX: 859 323 1931; tecurry{at}pop.uky.edu

This article has been cited by other articles:

				I. Van Vaerenbergh, L. Van Lommel, V. Ghislain, P. In't Veld, F. Schuit, H. M. Fatemi, P. Devroey, and C. Bourgain In GnRH antagonist/rec-FSH stimulated cycles, advanced endometrial maturation on the day of oocyte retrieval correlates with altered gene expression Hum. Reprod., May 1, 2009; 24(5): 1085 - 1091. [Abstract] [Full Text] [PDF]

				J. A.W. Stilley, R. Woods-Marshall, M. Sutovsky, P. Sutovsky, and K. L. Sharpe-Timms Reduced Fecundity in Female Rats with Surgically Induced Endometriosis and in Their Daughters: A Potential Role for Tissue Inhibitors of Metalloproteinase 1 Biol Reprod, April 1, 2009; 80(4): 649 - 656. [Abstract] [Full Text] [PDF]

				F. Gaytan, M. Gaytan, J. M. Castellano, M. Romero, J. Roa, B. Aparicio, N. Garrido, J. E. Sanchez-Criado, R. P. Millar, A. Pellicer, et al. KiSS-1 in the mammalian ovary: distribution of kisspeptin in human and marmoset and alterations in KiSS-1 mRNA levels in a rat model of ovulatory dysfunction Am J Physiol Endocrinol Metab, March 1, 2009; 296(3): E520 - E531. [Abstract] [Full Text] [PDF]

				C. K. Wieslander, D. D. Rahn, D. D. McIntire, J. F. Acevedo, P. G. Drewes, H. Yanagisawa, and R. A. Word Quantification of Pelvic Organ Prolapse in Mice: Vaginal Protease Activity Precedes Increased MOPQ Scores in Fibulin 5 Knockout Mice Biol Reprod, March 1, 2009; 80(3): 407 - 414. [Abstract] [Full Text] [PDF]

				C. K. Wieslander, S. I. Marinis, P. G. Drewes, P. W. Keller, J. F. Acevedo, and R. A. Word Regulation of Elastolytic Proteases in the Mouse Vagina During Pregnancy, Parturition, and Puerperium Biol Reprod, March 1, 2008; 78(3): 521 - 528. [Abstract] [Full Text] [PDF]

				T. J. Kaitu'u-Lino, N. B. Morison, and L. A. Salamonsen Estrogen Is Not Essential for Full Endometrial Restoration after Breakdown: Lessons from a Mouse Model Endocrinology, October 1, 2007; 148(10): 5105 - 5111. [Abstract] [Full Text] [PDF]

				H. Zhu, P.C.K. Leung, and C.D. MacCalman Expression of ADAMTS-5/implantin in human decidual stromal cells: regulatory effects of cytokines Hum. Reprod., January 1, 2007; 22(1): 63 - 74. [Abstract] [Full Text] [PDF]

				J. M. Castellano, M. Gaytan, J. Roa, E. Vigo, V. M. Navarro, C. Bellido, C. Dieguez, E. Aguilar, J. E. Sanchez-Criado, A. Pellicer, et al. Expression of KiSS-1 in Rat Ovary: Putative Local Regulator of Ovulation? Endocrinology, October 1, 2006; 147(10): 4852 - 4862. [Abstract] [Full Text] [PDF]

				S. Bu, C. Cao, Y. Yang, C. Miao, Z. Hu, Y. Cao, Q. A. Sang, and E. Duan Localization and temporal regulation of tissue inhibitor of metalloproteinases-4 in mouse ovary. Reproduction, June 1, 2006; 131(6): 1099 - 1107. [Abstract] [Full Text] [PDF]

				A. G. Braundmeier, A. T. Fazleabas, B. A. Lessey, H. Guo, B. P. Toole, and R. A. Nowak Extracellular Matrix Metalloproteinase Inducer Regulates Metalloproteinases in Human Uterine Endometrium J. Clin. Endocrinol. Metab., June 1, 2006; 91(6): 2358 - 2365. [Abstract] [Full Text] [PDF]

				Y. Wu, A. Kajdacsy-Balla, E. Strawn, Z. Basir, G. Halverson, P. Jailwala, Y. Wang, X. Wang, S. Ghosh, and S.-W. Guo Transcriptional Characterizations of Differences between Eutopic and Ectopic Endometrium Endocrinology, January 1, 2006; 147(1): 232 - 246. [Abstract] [Full Text] [PDF]

				M Shozu, N Minami, H Yokoyama, M Inoue, H Kurihara, K Matsushima, and K Kuno ADAMTS-1 is involved in normal follicular development, ovulatory process and organization of the medullary vascular network in the ovary J. Mol. Endocrinol., October 1, 2005; 35(2): 343 - 355. [Abstract] [Full Text] [PDF]

				T. J. Kaitu'u, J. Shen, J. Zhang, N. B. Morison, and L. A. Salamonsen Matrix Metalloproteinases in Endometrial Breakdown and Repair: Functional Significance in a Mouse Model Biol Reprod, October 1, 2005; 73(4): 672 - 680. [Abstract] [Full Text] [PDF]

				S Bauersachs, S E Ulbrich, K Gross, S E M Schmidt, H H D Meyer, R Einspanier, H Wenigerkind, M Vermehren, H Blum, F Sinowatz, et al. Gene expression profiling of bovine endometrium during the oestrous cycle: detection of molecular pathways involved in functional changes J. Mol. Endocrinol., June 1, 2005; 34(3): 889 - 908. [Abstract] [Full Text] [PDF]

				J. M. A. Emmen, J. F. Couse, S. A. Elmore, M. M. Yates, G. E. Kissling, and K. S. Korach In Vitro Growth and Ovulation of Follicles from Ovaries of Estrogen Receptor (ER){alpha} and ER{beta} Null Mice Indicate a Role for ER{beta} in Follicular Maturation Endocrinology, June 1, 2005; 146(6): 2817 - 2826. [Abstract] [Full Text] [PDF]

				W. B. Saunders, K. J. Bayless, and G. E. Davis MMP-1 activation by serine proteases and MMP-10 induces human capillary tubular network collapse and regression in 3D collagen matrices J. Cell Sci., May 15, 2005; 118(10): 2325 - 2340. [Abstract] [Full Text] [PDF]

				R. Pilka, H. Domanski, S. Hansson, P. Eriksson, and B. Casslen Endometrial TIMP-4 mRNA is high at midcycle and in hyperplasia, but down-regulated in malignant tumours. Coordinated expression with MMP-26 Mol. Hum. Reprod., September 1, 2004; 10(9): 641 - 650. [Abstract] [Full Text] [PDF]

				Y.-X. Liu, K. Liu, Q. Feng, Z.-Y. Hu, H.-Z. Liu, G.-Q. Fu, Y.-C. Li, R.-J. Zou, and T. Ny Tissue-Type Plasminogen Activator and Its Inhibitor Plasminogen Activator Inhibitor Type 1 Are Coordinately Expressed during Ovulation in the Rhesus Monkey Endocrinology, April 1, 2004; 145(4): 1767 - 1775. [Abstract] [Full Text] [PDF]

				M. Jo, L. E. Thomas, S. E. Wheeler, and T. E. Curry Jr Membrane Type 1-Matrix Metalloproteinase (MMP)-Associated MMP-2 Activation Increases in the Rat Ovary in Response to an Ovulatory Dose of Human Chorionic Gonadotropin Biol Reprod, April 1, 2004; 70(4): 1024 - 1032. [Abstract] [Full Text] [PDF]

				R. Wu, K. H. Van der Hoek, N. K. Ryan, R. J. Norman, and R. L. Robker Macrophage contributions to ovarian function Hum. Reprod. Update, March 1, 2004; 10(2): 119 - 133. [Abstract] [Full Text] [PDF]

				S. Oksjoki, O. Rahkonen, M. Haarala, E. Vuorio, and L. Anttila Differences in connective tissue gene expression between normally functioning, polycystic and post-menopausal ovaries Mol. Hum. Reprod., January 1, 2004; 10(1): 7 - 14. [Abstract] [Full Text] [PDF]

				P. Madan, P. J. Bridges, C. M. Komar, A. G. Beristain, R. Rajamahendran, J. E. Fortune, and C. D. MacCalman Expression of Messenger RNA for ADAMTS Subtypes Changes in the Periovulatory Follicle after the Gonadotropin Surge and During Luteal Development and Regression in Cattle Biol Reprod, November 1, 2003; 69(5): 1506 - 1514. [Abstract] [Full Text] [PDF]

				M. Hsieh, S. M. Mulders, R. R. Friis, A. Dharmarajan, and J. S. Richards Expression and Localization of Secreted Frizzled-Related Protein-4 in the Rodent Ovary: Evidence for Selective Up-Regulation in Luteinized Granulosa Cells Endocrinology, October 1, 2003; 144(10): 4597 - 4606. [Abstract] [Full Text] [PDF]

				T. E. Curry Jr. and K. G. Osteen The Matrix Metalloproteinase System: Changes, Regulation, and Impact throughout the Ovarian and Uterine Reproductive Cycle Endocr. Rev., August 1, 2003; 24(4): 428 - 465. [Abstract] [Full Text] [PDF]

				F. Gaytan, C. Bellido, M. Gaytan, C. Morales, and J. E. Sanchez-Criado Differential Effects of RU486 and Indomethacin on Follicle Rupture During the Ovulatory Process in the Rat Biol Reprod, July 1, 2003; 69(1): 99 - 105. [Abstract] [Full Text] [PDF]

				R. Pilka, C. Whatling, H. Domanski, S. Hansson, P. Eriksson, and B. Casslen Epithelial expression of matrix metalloproteinase-26 is elevated at mid-cycle in the human endometrium Mol. Hum. Reprod., May 1, 2003; 9(5): 271 - 277. [Abstract] [Full Text] [PDF]

				Q.-L. Li, S. A. Illman, H.-M. Wang, D.-L. Liu, J. Lohi, and C. Zhu Matrix metalloproteinase-28 transcript and protein are expressed in rhesus monkey placenta during early pregnancy Mol. Hum. Reprod., April 1, 2003; 9(4): 205 - 211. [Abstract] [Full Text] [PDF]

				D. M. Herrington Hormone Replacement Therapy and Heart Disease: Replacing Dogma With Data Circulation, January 7, 2003; 107(1): 2 - 4. [Full Text] [PDF]

				K. S. Simpson, C. M. Komar, and T. E. Curry Jr Localization and Expression of Tissue Inhibitor of Metalloproteinase-4 in the Immature Gonadotropin-Stimulated and Adult Rat Ovary Biol Reprod, January 1, 2003; 68(1): 214 - 221. [Abstract] [Full Text] [PDF]

				L. L. Espey and J. S. Richards Temporal and Spatial Patterns of Ovarian Gene Transcription Following an Ovulatory Dose of Gonadotropin in the Rat Biol Reprod, December 1, 2002; 67(6): 1662 - 1670. [Abstract] [Full Text] [PDF]

				T. E. Curry Jr and S. E. Wheeler Cellular Localization of Tissue Inhibitors of Metalloproteinases in the Rat Ovary Throughout Pseudopregnancy Biol Reprod, December 1, 2002; 67(6): 1943 - 1951. [Abstract] [Full Text] [PDF]

				K. L. Bruner-Tran, E. Eisenberg, G. R. Yeaman, T. A. Anderson, J. McBean, and K. G. Osteen Steroid and Cytokine Regulation of Matrix Metalloproteinase Expression in Endometriosis and the Establishment of Experimental Endometriosis in Nude Mice J. Clin. Endocrinol. Metab., October 1, 2002; 87(10): 4782 - 4791. [Abstract] [Full Text] [PDF]

				Q. Li, H. Wang, Y. Zhao, H. Lin, Q. A. Sang, and C. Zhu Identification and specific expression of matrix metalloproteinase-26 in rhesus monkey endometrium during early pregnancy Mol. Hum. Reprod., October 1, 2002; 8(10): 934 - 940. [Abstract] [Full Text] [PDF]

				L. J. Bakke, M. P.D. Dow, C. A. Cassar, M. W. Peters, J. R. Pursley, and G. W. Smith Effect of the Preovulatory Gonadotropin Surge on Matrix Metalloproteinase (MMP)-14, MMP-2, and Tissue Inhibitor of Metalloproteinases-2 Expression Within Bovine Periovulatory Follicular and Luteal Tissue Biol Reprod, June 1, 2002; 66(6): 1627 - 1634. [Abstract] [Full Text] [PDF]

				C. M. Komar and T. E. Curry Jr Localization and Expression of Messenger RNAs for the Peroxisome Proliferator-Activated Receptors in Ovarian Tissue from Naturally Cycling and Pseudopregnant Rats Biol Reprod, May 1, 2002; 66(5): 1531 - 1539. [Abstract] [Full Text]

				J. A. Lenhart, P. L. Ryan, K. M. Ohleth, S. S. Palmer, and C. A. Bagnell Relaxin Increases Secretion of Tissue Inhibitor of Matrix Metalloproteinase-1 and -2 during Uterine and Cervical Growth and Remodeling in the Pig Endocrinology, January 1, 2002; 143(1): 91 - 98. [Abstract] [Full Text] [PDF]