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Regular Article |
a Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A&M University, College Station, Texas 77843-2471
b Department of Veterinary Anatomy and Public Health, College of Veterinary Medicine, Texas A&M University, College Station, Texas 77843
c Departments of Medicine, Molecular and Cellular Biology and Immunology, Baylor College of Medicine, Houston, Texas 77030
ABSTRACT
The enzymes which comprise the 2',5'-oligoadenylate synthetase (OAS) family are interferon (IFN) stimulated genes which regulate ribonuclease L antiviral responses and may play additional roles in control of cellular growth and differentiation. This study characterized OAS expression in the endometrium of cyclic and pregnant ewes as well as determined effects of IFN
and progesterone on OAS expression in cyclic or ovariectomized ewes and in endometrial epithelial and stromal cell lines. In cyclic ewes, low levels of OAS protein were detected in the endometrial stroma (S) and glandular epithelium (GE). In early pregnant ewes, OAS expression increased in the S and GE on Day 15. OAS expression in the lumenal epithelium (LE) was not detected in uteri from either cyclic or pregnant ewes. Intrauterine administration of IFN stimulated OAS expression in the S and GE, and this effect of IFN was dependent on progesterone. Ovine endometrial LE, GE, and S cell lines responded to IFN with induction of OAS proteins. In all three cell lines, the 40/46-kDa OAS forms were induced by IFN, whereas the 100-kDa OAS form appeared to be constitutively expressed and not affected by IFN. The 69/71-kDa OAS forms were induced by IFN in the S and GE cell lines, but not in the LE. Collectively, these results indicate that OAS expression in the endometrial S and GE of the early pregnant ovine uterus is directly regulated by IFN from conceptus and requires the presence of progesterone.
First decision: 16 October 2000.
1 Supported by grant HD32534 from the National Institutes of Health (NIH) to F.W.B. and T.E.S., BARD grant US-2643-95 to F.W.B., U.S. Department of Agriculture-NRICGP grant 95-37203-2185 to F.W.B. and R.C.B., and in part by NIH grants P30 ES09106 and 1-F32-HD08501 to G.A.J.
2 Correspondence: Thomas E. Spencer, Center for Animal Biotechnology and Genomics, 442 Kleberg Center, 2471 TAMU, Texas A&M University, College Station, TX 77843-2471. FAX: 979 862 2662; tspencer{at}ansc.tamu.edu
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