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Effect of Age and Breeding Season on the Developmental Capacity of Oocytes from Unstimulated and Follicle-Stimulating Hormone-Stimulated Rhesus Monkeys¹

^a Department of Primate Biology, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming 650223, China ^b The China-U.S. Primate Biology Laboratory, Kunming Institute of Zoology and University of Wisconsin-Madison, Madison, Wisconsin 53706 ^c Department of Animal Health and Biomedical Sciences, University of Wisconsin-Madison, Madison, Wisconsin 53706

ABSTRACT

Effects of age and season on the developmental capacity of oocytes from unstimulated and FSH-stimulated rhesus monkeys were examined. Immature cumulus-oocyte complexes were matured in vitro in modified CMRL-1066 medium containing 20% bovine calf serum and subjected to in vitro fertilization followed by embryo culture. After fertilization, ova from unstimulated prepubertal monkeys displayed lower development to morula (4%) than those from unstimulated adult females (18% in breeding season and 22% in nonbreeding season). No developmental difference was found between ova from unstimulated adult monkeys in breeding and nonbreeding seasons. However, ova from FSH-primed prepubertal monkeys displayed greater development to blastocyst stage (54%) than those from adult monkeys in the breeding season (16%) and nonbreeding season (0%); and ova from FSH-primed adult females in the breeding season had significantly (P < 0.05) greater developmental competence than those obtained in the nonbreeding season (morula stage, 54% vs. 3%; blastocyst stage, 16% vs. 0%). These data indicate that 1) rhesus monkey oocytes acquire developmental competence in a donor age-dependent manner, and 2) animal age and breeding season modulate the effect of FSH on oocyte developmental competence in the rhesus monkey.

FOOTNOTES

First decision: 10 October 2000.

¹ Supported by the Talent fund of Yunnan Province (96C0003G), China; projects under the Major State Basic Research Development Program, G2000016108; and is a Key Project of the Chinese Academy of Sciences KSCX1-05-02. Support was also provided by the National Institutes of Health (grants RR13439, HD-22023, and RO3-TW00840).

² Correspondence: Weizhi Ji, Director, The Kunming Institute of Zoology, The Chinese Academy of Science, 32 Jiao Chang Dong Lu, Kunming, Yunnan 650223, People's Republic of China. FAX: 86 871 5139413; wji{at}mail.kiz.ac.cn

³ Current address: Barry D. Bavister, University of New Orleans, Department of Biological Sciences, and Audubon Institute Center for Research of Endangered Species, 14001 River Road, New Orleans, LA 70131.

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