HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Whitney, A. C. Articles by Clark, A. S. Search for Related Content PubMed PubMed Citation Articles by Whitney, A. C. Articles by Clark, A. S. Agricola Articles by Whitney, A. C. Articles by Clark, A. S.

Effects of Acute Stanozolol Treatment on Puberty in Female Rats¹

^a Department of Psychological and Brain Sciences, Dartmouth College, Hanover, New Hampshire 03755

ABSTRACT

The effects of anabolic-androgenic steroid (AAS) abuse on the onset of puberty in female adolescents are largely unknown. This study assessed the acute effects of one AAS, stanozolol, on pubertal onset in the female rat. A single injection of stanozolol (5 mg/kg) on Postnatal Day (PN) 21 advanced vaginal opening but did not alter the onset of vaginal estrus. Higher doses of stanozolol treatment (10 and 25 mg/kg) also advanced vaginal opening but had no effect on vaginal estrus. The advancement of vaginal opening by stanozolol (5 mg/kg) was prevented by the concomitant administration of the pure antiestrogen ICI 182,780 (1 mg/kg) on PN20–22. Administration of the androgen receptor antagonist flutamide (10 mg/kg twice daily) on PN20–22 had no effect on the advancement of vaginal opening by stanozolol. Stanozolol treatment also advanced vaginal opening in ovariectomized rats. Perivaginal injections of a low dose of stanozolol (0.05 mg) on PN21 and PN23 also advanced vaginal opening. These results suggest that stanozolol is acting directly at estrogen receptors in the vaginal epithelium to advance vaginal opening and that prepubertal stanozolol treatment does not induce true precocious puberty.

FOOTNOTES

First decision: 18 October 2000.

¹ This work was supported by NIH grant DA08574 to A.S.C.

² Correspondence: Ann S. Clark, Department of Psychological and Brain Sciences, Dartmouth College, 6207 Moore Hall, Hanover, NH 03755. FAX: 603 646 1419; ann.s.clark{at}dartmouth.edu

This article has been cited by other articles:

				A. S. Clark, M. C. Kelton, and A. C. Whitney Chronic Administration of Anabolic Steroids Disrupts Pubertal Onset and Estrous Cyclicity in Rats Biol Reprod, February 1, 2003; 68(2): 465 - 471. [Abstract] [Full Text] [PDF]