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Regular Article |
a Department of Animal Biology, University of Valencia, Burjassot, 46100 Valencia, Spain
b Unity of Epidemiology and Statistics, Valencian School for Health Studies, 46017 Valencia, Spain
c Department of Pediatrics, Obstetrics and Gynecology, University of Valencia, 46010 Valencia, Spain
We analyzed the long-term effects of postovulatory aging of mouse oocytes on reproductive fitness and longevity of offspring. Hybrid (C57BL/6JIco x CBA/JIco) parental generation (F0) females were artificially inseminated at 13 h (
1 h postovulation) or 22 h (10 h postovulation) after GnRH injection. Reproductive fitness of first generation (F1) females was tested from the age of 28 wk until the end of their reproductive life. In males, the testing period ranged from the age of 2 yr until their natural death. Experimental F1 females exhibited longer between-labor intervals, decreased frequency of litters, and lower total number of litters and offspring born. Experimental second generation (F2) pups displayed teratogenic defects, higher preweaning mortality, and decreased body weight at weaning. Incidence of infertility was higher in experimental F1 males, which translated into lower total number of offspring born when compared with the control group. Life expectancy of F1 offspring was decreased in the experimental group. These results clearly show that postovulatory aging of mouse oocytes decreases reproductive fitness and longevity of offspring.
1 Supported by grant GV99-138-1-04 from the Conselleria de Cultura, Educació i Ciència, Generalitat Valenciana, grant 1FD97-1035-C02-01 from the CICYT (Ministry of Education and Culture, Madrid, Spain) and the European Union, and grants FIS 00/0668 and FIS 01/0138 from the Instituto de Salud Carlos III, Fondo de Investigación Sanitaria, Ministerio de Sanidad y Consumo.
2 Correspondence: Juan J. Tarín, Department of Pediatrics, Obstetrics and Gynecology, Faculty of Medicine, University of Valencia, Avda. Blasco Ibañez 17, 46010 Valencia, Spain. FAX: 34 96 386 4815; tarinjj{at}uv.es
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