| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Minireview |
a Institute for Hormone and Fertility Research, University of Hamburg, D-22529 Hamburg, Germany
Lysophosphatidic acid (LPA) belongs to a new family of lipid mediators that are endogenous growth factors and that elicit diverse biological effects, usually via the activation of G protein-coupled receptors. LPA can be generated after cell activation through the hydrolysis of preexisting phospholipids in the membranes of stimulated cells. A dramatic elevation of LPA levels was found in serum of patients suffering from ovarian carcinoma. Because these high LPA amounts can be detected as early as stage I of the disease, LPA has been introduced as a new marker for ovarian cancer. Progression of the malignancy is correlated with a differential expression of various LPA receptor subtypes. The presence of LPA in the follicular fluid of healthy individuals implicates that this biological mediator may be relevant to normal ovarian physiology. LPA induces proliferation and mitogenic signaling of prostate cancer cells, and a novel LPA receptor isoform has been recognized in healthy prostate tissues. This evidence indicates multiple roles for LPA in both male and female reproductive physiology and pathology. In this review, we summarize the literature on LPA generation, the way it is degraded, and the mechanisms by which signals are transduced by various LPA receptors in reproductive tissues, and we discuss possible future research directions in these areas.
1 Correspondence: L.T. Budnik, Institute for Hormone and Fertility Research, University of Hamburg, Grandweg 64, D-22529 Hamburg, Germany. FAX: 4940 56190864; budnik{at}ihf.de
This article has been cited by other articles:
|
|
 |
|
  S.-U. Chen, H. Lee, D.-Y. Chang, C.-H. Chou, C.-Y. Chang, K.-H. Chao, C.-W. Lin, and Y.-S. Yang Lysophosphatidic Acid Mediates Interleukin-8 Expression in Human Endometrial Stromal Cells through Its Receptor and Nuclear Factor-{kappa}B-Dependent Pathway: A Possible Role in Angiogenesis of Endometrium and Placenta Endocrinology, November 1, 2008; 149(11): 5888 - 5896. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Ye Lysophospholipid signaling in the function and pathology of the reproductive system Hum. Reprod. Update, September 1, 2008; 14(5): 519 - 536. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Ye, M. K. Skinner, G. Kennedy, and J. Chun Age-Dependent Loss of Sperm Production in Mice via Impaired Lysophosphatidic Acid Signaling Biol Reprod, August 1, 2008; 79(2): 328 - 336. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Zhao, D. He, J. Zhao, L. Wang, A. R. Leff, E. Wm. Spannhake, S. Georas, and V. Natarajan Lysophosphatidic Acid Induces Interleukin-13 (IL-13) Receptor {alpha}2 Expression and Inhibits IL-13 Signaling in Primary Human Bronchial Epithelial Cells J. Biol. Chem., April 6, 2007; 282(14): 10172 - 10179. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. T. Budnik and B. Brunswig-Spickenheier Differential effects of lysolipids on steroid synthesis in cells expressing endogenous LPA2 receptor J. Lipid Res., May 1, 2005; 46(5): 930 - 941. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. T. Budnik, B. Brunswig-Spickenheier, and A. K. Mukhopadhyay Lysophosphatidic Acid Signals through Mitogen-Activated Protein Kinase-Extracellular Signal Regulated Kinase in Ovarian Theca Cells Expressing the LPA1/edg2-Receptor: Involvement of a Nonclassical Pathway? Mol. Endocrinol., August 1, 2003; 17(8): 1593 - 1606. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
