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Viewpoint on the Functionality of the Human Leukocyte Antigen-G Null Allele at the Fetal-Maternal Interface

^a Service de Recherches en Hémato-Immunologie, CEA-DSV-DRM, Hôpital St-Louis,> Institut Universitaire d'Hématologie, 75475 Paris, Cedex 10, France ^b Fondation Jean Dausset, CEPH, 75010 Paris, France

The description of healthy individuals homozygous for the human leukocyte antigen-G (HLA-G) null allele raised doubts about the role of HLA-G in fetal-maternal tolerance. In light of recent results, we discuss this point by considering the potential activity of this null allele that might, indeed, produce functional truncated HLA-G molecules. In this context, we have recently described that, like the full-length HLA-G1, the HLA-G2, -G3, and -G4 truncated isoforms may be expressed at the cell surface and may modulate both innate and acquired immune responses.

¹ Correspondence: Edgardo D. Carosella, Service de Recherches en Hémato-Immunologie, CEA-DSV-DRM, Hôpital St-Louis, Institut Universitaire d'Hématologie, 1 avenue Claude Vellefaux, 75475 Paris, Cedex 10, France. FAX: 33 1 48 03 19 60; carosella{at}dsvidf.cea.fr